慢性阻塞性肺疾病患者采用噻托溴胺联合呼吸操训练对其肺通气功能、生活质量以及运动耐力的影响

Effect of tiotropium combined with respiratory exercises on pulmonary ventilation function,quality of life and exercise tolerance in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病患者采用噻托溴胺联合呼吸操训练对其肺通气功能、生活质量以及运动耐力的影响。方法将2015年8月-2016年8月收治的78例稳定期慢性阻塞性肺疾病患者按照随机数字表法分为对照组(噻托溴胺)与观察组(噻托溴胺联合呼吸操训练),各39例。检测两组患者治疗前、后FEV1占预计值百分比(FEV1%预计值)来评价其肺功能情况;采用圣乔治呼吸疾病问卷(SGRQ评分)评价两组患者治疗前后生活质量情况,采用6 min步行距离评价两组患者治疗前、后运动耐力。结果观察组治疗后FEV1%预计值为(65.96±6.11)%,明显高于对照组(58.63±5.59)%,差异有统计学意义(P<0.05);观察组治疗后SGRQ评分(45.63±4.22)分,明显低于对照组(55.86±6.38)分,差异有统计学意义(P<0.05);观察组治疗后6 min步行距离为(441.25±25.98)m,明显长于对照组(410.19±18.79)m,差异有统计学意义(P<0.05);两组患者治疗后FEV_1%预计值、6 min步行距离明显优于治疗前,而SGRQ评分较治疗前显著下降,差异有统计学意义(P<0.05)。结论稳定期慢性阻塞性肺疾病患者采用噻托溴铵联合呼吸操训练可有助于改善患者肺功能,提高运动耐力,更好的改善生活质量。

Objective To investigate the effect of tiotropium combined with respiratory exercises on pulmonary ventilation function,quality of life and exercise tolerance in patients with chronic obstructive pulmonary disease.Methods 78 patients with stable chronic obstructive pulmonary disease(COPD)from August 2015 to August 2016 were randomly divided into the control group(tiotropiumamine)and the observation group(tiotropium combined with breathing exercise).The pulmonary function of FEV 1 was measured before and after treatment.The quality of life before and after treatment was evaluated by St George's Respiratory Disease Questionnaire.6-minute walking distance was used to evaluate the quality of life of the two groups before treatment and after exercise endurance.Results The percentage of predicted FEV1 in the observation group was(65.96±6.11)%,which was significantly higher than that in the control group(58.63±5.59)%(P<0.05).The score of St.George Respiratory Disease Questionnaire was(45.63±4.22)and(55.86±6.38)respectively in the observation group and the control group(P<0.05).6-minute walking distance was(441.25±25.98)and(410.19±18.79)in the observation group and the control group respectively(P<0.05).FEV 1%predicted value,6-min walking distance and St George's Respiratory Disease Questionnaire score improved more significantly in the observation group than in the control group(P<0.05).Conclusion Tiotropium combined with breathing exercises can improve lung function,exercise tolerance and their quality of life in treatment of stable COPD patients.