探讨局部亚低温对急性重症脑梗死患者应激激素的影响及临床意义

Investigation of the Influence of Local Mild Hypothermia on Stress Hormones in Patients with Acute Severe Cerebral Infarction and Its Clinical Significance

目的:探讨局部亚低温对急性重症脑梗死患者应激激素的影响及临床意义。方法:选取96例急性重症脑梗死患者进行分型,随机将其分为两组(常规组和亚低温组),各48例,常规组采取常规治疗,亚低温组在此基础上采取亚低温治疗,比较两组患者临床疗效。结果:治疗后,亚低温组治愈率均优于常规组,致残率低于常规组,差异有统计学意义(P<0.05);治疗后,两组患者神经功能缺损评分均低于治疗前,同时亚低温组患者神经功能缺损评分低于常规组,差异有统计学意义(P<0.05);治疗前,两组应激激素水平比较差异无统计学意义(P>0.05),治疗后亚低温组患者应激激素水平除CRH外其他应激激素水平均低于常规组,差异具有统计学意义(P>0.05)。结论:亚低温治疗不仅有助于改善急性重症脑梗死患者神经功能情况,同时还能明显减少应激激素水平,其值得推广借鉴。

Objective:To investigate the influence of local mild hypothermia on stress hormones in patients with acute severe cerebral infarction and its clinical significance.Methods:96 cases of patients with acute severe cerebral infarction were classified,and were randomly divided into two groups(the conventional group and the mild hypothermia group),each of 48 cases.The conventional group was given routine therapy,while the mild hypothermia group was taken on the basis of mild hypothermia treatment,and clinical curative effect was compared between two groups of patients.Results:The mild hypothermia group cure rate was higher than the conventional groups while the disability rate was lower than the conventional group(P<0.05)after the treatment.There were statistically significant differences;neurological deficits scores in two groups of the patients were lower than those before the treatment,while the scores of patients with mild hypothermia group neurological deficit were lower than that in the conventional group(P<0.05).There were statistically significant differences.Before the treatment,there were no ststistically significant differences in two groups of patients in the stress hormone level(P>0.05).All those items in the stress hormone levels were lower than the conventional group except for CRH,and there was no statistically significant difference in stress hormone levels in patients with CRH and mild hypothermia group after the treatment,compared with the conventional group(P>0.05).Conclusions:The mild hypothermia therapy can not only improve the neurological function of patients with acute severe cerebral infarction,but also reduce the level of stress hormone,which is worth popularizing and using for the reference.