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不同质子泵抑制剂对PCI术后氯吡格雷抗血小板效果的影响分析 被引量:1

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摘要 目的:研究在冠状动脉介入术(PCI)患者术后不同质子泵抑制剂对氯吡格雷抗血小板的影响。方法:以随机数字表法将126例冠状动脉介入术患者随机分为3组,为泮托拉唑组(n=42)、奥美拉唑组(n=42)、参照组(n=42),参照组患者不应用质子泵抑制剂,泮托拉唑组患者予以泮托拉唑,奥美拉唑组患者予以奥美拉唑,分析对比3组冠状动脉介入术患者术心血管事件发生率、血小板阻抗、PAg T、GPIIb、CD62P、出血并发症发生率等指标。结果:泮托拉唑组、奥美拉唑组、参照组冠状动脉介入术患者术后心源性死亡、紧急靶血管血运重建、脑卒中、亚急性支架内血栓、非致死性急性心肌梗死等发生率以及血小板阻抗、PAg T、GPIIb、CD62P等指标之间对比,差异无统计学意义(P>0.05)。泮托拉唑组、奥美拉唑组冠状动脉介入术患者术后出血并发症发生率显著低于参照组,差异有统计学意义(P<0.05)。结论:在冠状动脉介入术(PCI)患者术后应用泮托拉唑、奥美拉唑具有相似的作用,不会降低阿司匹林与氯吡格雷联合治疗的效果,但可显著减少发生出血事件的几率,值得应用。
作者 周芃
出处 《山西职工医学院学报》 CAS 2018年第1期81-83,共3页 Journal of Shanxi Medical College for Continuing Education
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  • 1任艺虹,盖鲁粤,杨庭树,王洪叶,王禹,邢攸红,林琳,刘春雪.改良血栓弹力图法和流式细胞测定技术对血小板活性抑制程度的比较研究[J].中华心血管病杂志,2007,35(4):366-367. 被引量:37
  • 2Derry S, Loke YK. Risk of gastrointestinal haemorrhage withlong term use of aspirin: meta-analysis [J]. BMJ, 2000,321(7270): 1183-1187.
  • 3Lanas A, Scheiman J. Low-dose aspirin and uppergastrointestinal damage: epidemiology, prevention andtreatment[J]. Curr Med Respin, 2007,23(1): 163-173.
  • 4Ng FH,Wong SY, Lam KF, et al. Gastrointestinal bleeding inpatients receiving a combination of aspirin, clopidogrel andenoxaparin in aeute coronary syndrome[J]. Am JGastroenterol, 2008,103(4): 865-871.
  • 5Bhatt DI, Scheiman I,Abraham NS, et al. ACCF/ACG/AHA2008 expert consensus document on reducing thegastrointestinal risks of antiplatelet therapy and NSAID use:a report of the American College of Cardiology FoundationTask Force on Clinical Expert Consensus Documents[J]. JAm Coll Cardiol, 2008, 52(18): 1502-1517.
  • 6Siler-Matula JM, Jilma B, Schrok, et al. Effects of protonpump inhibitors on clinical outcome in patients treated withclopidogrel: a systematic review and meta-analysis[J].Thromb Haemost, 2010,8(12): 2624-2641.
  • 7Ho PM, Maddox TM, Wang I,et al. Risk of adverseoutcomes associated with concomitant use of clopidogrel andproton pump inhibitors following acute coronarysyndrome[J]. JAMA, 2009,301(9): 937-944.
  • 8Burkard T, Kaiser C,Brunner-La Rocca HP, et al. Combinedclopidogrel and proton pump inhibitor therapy is associatedwith higher cardiovascular event rates after percutaneouscoronary intervention: a report from the BASKET trial[J]. JIntern Med, 2012,271(3): 257-263.
  • 9Gupta E, Bansal D, Sotos J,et al. Risk of adverse clinicaloutcomes with concomitant use of clopidogrel and protonpump inhibitors following percutaneous coronaryintervention!;J]. Dig Dis Sci,2010, 55(7): 1964-1968.
  • 10Sibbing D, Morath T, Stegherr J, et al. Impact of protonpump inhibitors on the antiplatelet effects of clopidogreI[J].Thromb Haemost, 2009,101(4): 714-719.

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