血清胸腺激酶1、CA125监测在局部进展期宫颈鳞癌患者放化疗中的临床意义

Clinical significance of detecting serum thymidine kinase 1 and CA125 in the locally advanced cervical squamous cell carcinoma before and after chemoradiotherapy

目的观察血清胸腺激酶1(S-TK1)及CA125在局部进展期子宫颈鳞癌患者放化疗前后检测的意义。方法检测38例局部进展期子宫颈鳞癌患者放化疗前后和30例健康体检者的S-TK1水平及CA125水平。结果观察组S-TK1水平及CA125水平均高于健康组(P<0.05);观察组治疗后无疾病进展的患者S-TK1水平及CA125水平较放化疗前下降(P<0.05),疾病进展的患者S-TK1水平及CA125水平较放化疗前上升(P<0.05);观察组治疗前各临床病理特征组间的S-TK1水平及CA125水平差异无统计学意义(P>0.05)。结论监测S-TK1水平及CA125水平对评估局部进展期子宫颈鳞癌患者的疗效具有一定的临床价值。

To investigate the significance of detecting serum thymidine kinase 1(S-TK1)and CA125 in the locally advanced cervical squamous cell carcinoma before and after chemoradiotherapy.Serum levels of S-TK1 and CA125 in 38 patients with locally advanced cervical squamous cell carcinoma before and after chemoradiotherapy and 30 healthy controls were measured.The serum levels of S-TK1 and CA125 in the patients was significantly higher than that in the controls(P<0.05(.Compared to before chemoradiotherapy,the serum levels of S-TK1 and CA125 were significantly decreased in patients with disease under control(P<0.05(while the levels of the two biomarkers were significantly increased in the patients with disease progression after chemoradiotherapy(P<0.05(.There was no significant difference in the level of S-TK1 and CA125 among the clinic-pathological features before treatment(P<0.05(.The detection of S-TK1 and CA125 may have significance in evaluation of chemoradiotherapy efficacy in patients with locally advanced cervical squamous cell carcinoma.