KL-6对原发性干燥综合征合并肺间质病变与肺部感染的鉴别诊断价值

Differential diagnosis value of serum KL-6 in primary sjogren's syndrome complicated with interstitial lung disease and pulmonary infection

目的讨论血清KL-6对原发性干燥综合征(pSS)合并肺间质病变(ILD)与肺部感染的鉴别诊断价值。方法 116例pSS患者中,pSS并ILD组35例、pSS并肺部感染组28例、pSS无肺部病变组53例。采用ELISA法测定3组血清KL-6浓度,分析其在pSS患者合并肺间质病变与肺部感染中的鉴别诊断价值。结果 pSS合并ILD组患者KL-6水平高于pSS合并肺部感染组、pSS无肺部病变组,差异有统计学意义(P<0.05)。pSS合并肺部感染组、pSS无肺部病变组之间血清KL-6差异无统计学意义(P>0.05)。以500 U/ml为阳性标准,KL-6对pSS并ILD诊断的敏感性为91.4%,特异性为89.3%。结论血清KL-6水平是pSS合并ILD特异性和敏感性的血清学指标,可用来在pSS患者中鉴别ILD和肺部感染。

Objective To investigate the differential diagnostic value of KL-6 in primary sjogren’s syndrome(pSS)with interstitial lung disease(ILD)and with infectious lung disease.Methods Among 116 pSS patients,35 cases of ILD,28 cases of infectious lung disease,53 cases without lung disease.ELISA method was adopted to measure the serum KL-6 level of the three groups,and to analyze the differential diagnosis of pulmonary disease in pSS patients.Results The serum KL-6 in pSS with ILD was higher than pSS with infectious lung disease group and pSS without lung disease group(P<0.05).No statistically significant difference was found in KL-6 level between pSS without lung disease,patients with infectious lung disease(P>0.05).While the 500 U/ml was regarded as positive standard,the sensitivity of KL-6 to pSS with ILD was 91.4%,and the specificity was 89.3%.Conclusion Serum KL-6 level is a specific and sensitive marker for pSS with ILD,which can be used to identify ILD and pulmonary infection.