老年心房颤动患者应用华法林的出血风险及预防分析

Risk and prevention of warfarin in elderly patients with atrial fibrillation

目的分析老年心房颤动患者应用华法林的出血风险,并给出相应的对策。方法回顾分析2014年7月~2017年1月收治的101例心房颤动的老年患者,其中67例使用华法林,为观察组,34例使用阿司匹林,为对照组,分析两组患者的出血情况以及治疗情况。结果观察组患者有7例出血,出血发生率为10.44%,对照组患者有2例出血,出血发生率为5.88%,两组差异无统计学意义(P>0.05);观察组脑卒中、外周动脉栓塞等血栓发生率均显著低于对照组,差异均有统计学意义(P<0.05)。结论华法林用于老年心房颤动治疗具有一定的出血风险,但是总体而言安全系数较高,在临床使用中应严密观察。

Objective To analyze the risk of warfarin in elderly patients with atrial fibrillation and to give a countermeasure.Methods A retrospective analysis of 101 cases of atrial fibrillation in elderly patients was undergoing from July 2014 to January 2017,including 67 cases of the use of warfarin defined as the observation group,34 cases of the use of aspirin as control group,analysis and treatment of hemorrhage in the patients of the two groups.Results The observation group of 7 cases of hemorrhage,bleeding rate was 10.44%,control group 2 cases of hemorrhage,bleeding rate was 5.88%,there was no significant difference between the two groups(P>0.05);observation group of stroke,peripheral arterial embolism and thrombosis were significantly lower than the control group(P<0.05).Conclusion Warfarin has some risk of bleeding in the treatment of senile atrial fibrillation,but in general,the safety factor is high,and the vital signs should be closely observed in clinical use.