血清标志物预测子痫前期的研究进展

Research progress of serum markers predict preeclampsia

子痫前期是妊娠期特发和常见的合并症之一,不仅影响孕产妇健康,还可影响胎儿远期预后,其发病机制至今不清,对其发病机制的研究一直是产科领域的热点。关于其发生机制主要有胎盘或滋养细胞缺血缺氧学说、氧化应激学说、免疫调节异常学说、遗传学说和血管内皮损伤学说等。本文整合相关资源,总结近年研究中发现的可帮助预测子痫前期的血清标志物,更新研究理念,促进子痫前期病因研究发展。

Preeclampsia is one of the most common complications in pregnancy period,which not only affects maternal health,but also the fetal.However,the mechanism of the pathogenesis is still unclear.Therefore,the research on preeclampsia is always a hotspot.There are several hypothesis to describe the mechanism of the preeclampsia occurrence,including hypoxia,oxidative stress,abnormal immunomodulation,genetics and vascular endothelial injury.This article is to summarize and update the evidence regarding the effects of serum markers for preventing preeclampsiain order to promote the development of the etiology of preeclampsia.