生物标志物用于肺癌早期诊断的研究进展

Advances in application of biomarkers in early diagnosis of lung cancer

肺癌是全球范围内发病率和死亡率最高的恶性肿瘤类型,早期诊断对改善肺癌患者的预后至关重要。肺癌的发生是多因素、多基因参与的复杂过程。近年来,生物标志物的异常表达已成为肺癌早期诊断研究中的热点。随着检测技术的快速发展,肺癌自身抗体、循环肿瘤DNA、循环肿瘤细胞、微小RNA等生物标志物不断被发现。本文就生物标志物用于肺癌早期诊断的研究进展作一概要介绍。

Lung cancer is the type of malignancy with the highest morbidity and mortality worldwide.Early diagnosis is of great significance for improving the prognosis of lung cancer.The occurrence of lung cancer is a complex process involving in multiple factors and multiple genes.In recent years,the abnormal expression of biomarkers has become a hot spot in the research of early diagnosis of lung cancer and some new biomarkers,such as autoantibodies,circulating tumor DNA,circulating tumor cells,and microRNA have been emerging with the rapid development of detection technology.The research progress in this field is briefly introduced in this article.