线粒体与新陈代谢和细胞死亡

The Role of Mitochondria in Metabolism and Cell Death

线粒体在能量代谢、应激响应和生物合成方面扮演重要角色。除了在细胞能量上的重要作用,线粒体还是细胞内活性氧产生的主要位点,维持细胞内钙离子稳态。线粒体内细胞凋亡诱导因子的释放,会诱导细胞死亡。本文简要概述了线粒体在能量代谢和细胞死亡过程中所起到的作用。

Mitochondria play a key role in energy metabolism,control of stress responses and biosynthetic processes.Beyond its well-established role in cellular energetics,mitochondria are the primary source of intracellular reactive oxygen species(ROS)generation and are involved in cellular Ca2+homeostasis,they contain several apoptosis inducing factors(AIF)that can be unleashed to promote cell death.Here we report some observations that contribute to knowledge of the role of mitochondria in metabolism and cell death.