丹参对步枪打靶所致急性声损伤的预防作用观察

Preventive Effect of Salvia Miltiorrhiza on Acute Acoustic Trauma Induced by Rifle Shooting

目的观察丹参对脉冲噪声所致暂时性阈移(temporary threshold shifts,TTS)的影响,探讨丹参对急性声损伤(acute acoustic trauma,AAT)的保护作用。方法 62例新兵训练营的男性士兵随机分为观察组和对照组,每组31例,观察组在训练前连续3天及训练后1天口服丹参片,每次780mg,每天3次;对照组同时间段服用安慰剂(淀粉片)。分别于实弹训练前72 h和训练后6 h对两组受试者右耳行纯音听阈检测,比较两组结果。结果实弹训练前观察组与对照组右耳低频(0.5、1、2 kHz)平均听阈(puretone average,PTA)分别为16.32±6.12、16.21±5.42 dB HL,高频(4、6、8kHz)平均听阈(high pure tone average,HPTA)分别为14.22±5.16、14.89±5.38 dB HL,两组比较差异均无统计学意义(P>0.05)。实弹训练6 h后观察组与对照组右耳低频平均听阈分别为21.88±5.71、21.66±6.62 dB HL,差异无统计学意义(P>0.05);高频平均听阈分别为25.89±7.97、39.75±7.84 dB HL,观察组高频平均听阈和TTS低于对照组(P<0.01)。结论丹参可降低急性声损伤所致的高频TTS,对急性声损伤有潜在的预防作用。

Objective To study the protective effects of salvia miltiorrhiza on acute acoustic trauma(AAT)showed by temporary threshold shifts(TTS)induced by impulse noise.Methods A total of 62 male soldiers from a boot camp were randomly divided into the experimental group and the control group,each with 31 persons.The experimental group was treated with salvia miltiorrhiza,and the control group with placebo.Salvia miltiorrhiza was taken orally at the dosage of 780 mg each time,three times a day for 3 consecutive days before the live fire training and 1 day after the live fire training.The pure tone thresholds of right ears of these two groups were measured and compared 72 hours before live fire training and 6 hours after the live fire training.Results The pure-tone averages at 0.5,1 and 2 kHz of the right ears of the experimental group and the control group before live fire training were 16.32±6.12 dB and 16.21±5.42 dB,respectively,and the averages at 4,6 and 8 kHz were 14.22±5.16 dB and 14.89±5.38 dB,respectively.There were no significant differences between the 2 groups(P>0.05).The PTAs of the right ears of the experimental group and the control group 6 hours after live fire training were 21.88±5.71 dB and 21.66±6.62 dB,respectively(P>0.05),while the HPTAs were 25.89±7.97 dB and 39.75±7.84 dB,respectively(P<0.01).There were significant differences in TTS between the two groups at 4,6 and 8 kHz(P<0.01).Conclusion Salvia miltiorrhiza can reduce TTS at high frequencies induced by AAT.It has a potential preventive effect on AAT.