摘要
目的优选清补通络浓缩丸提取工艺。方法采用高效液相色谱(HPLC)法测定黄芩苷含量,以黄芩苷含量及出膏率为考察指标,正交试验优选最佳提取工艺。结果最佳提取工艺为料液比1∶10,提取2次,每次1 h;在此条件下,黄芩苷含量为4.49 mg/g,出膏率为4.84%。结论优选的清补通络浓缩丸提取工艺合理、稳定、效果良好,可为清补通络浓缩丸及其他中药新药的生产提供试验依据。
Objective To optimize the extraction process of Qingbutongluo Concentrated Pills.Methods The content of baicalin was determined by HPLC,and the optimum extraction process was optimized by orthogonal test with the content of baicalin and the yield of extraction as the indexes.Results The optimum extraction process is as follows:the ratio of material to liquid was 1:10 with 2 times of extraction,1h each time.Under this condition,the content of baicalin was 4.49 mg/g,and the yield of extraction was 4.84%.Conclusion The optimized extraction process is reasonable,stable and effective,which can provide the experimental basis for the production Qingbutongluo Concentrated Pills and other new medicines of traditional Chinese medicine.
作者
王林
王婷媛
邱远金
林芳花
周卫刚
刘纪杉
李江涛
朱国强
高辉
Wang Lin;Wang Tingyuan;Qiu Yuanjin;Lin Fanghua;Zhou Weiguo;Liu Jishan;Li Jiangtao;Zhu Guoqiang;Gao Hui(Xinjiang Institutes of Traditional Chinese Medica end Ethnic Medica,Urumqi,Xinjiang,China 830002;School of Life Science,Guangdong Huizhou University,Huizhou,Guangdong,China 516007;Xinjiang Uygur Autonomous Region Sixth People’s Hospital,Urumqi,Xinjiang,China 830013)
出处
《中国药业》
CAS
2018年第4期10-12,共3页
China Pharmaceuticals
基金
新疆维吾尔自治区中医民族医药管理局新疆地产中药民族药新药研发培育项目[2016-02-07]