帕罗西汀联合奥氮平治疗对精神分裂症患者S100B、S100β及Repetin的影响

Effect of paroxetine combined with olanzapine on S100B,S100β and Repetin in schizophrenic patients

目的研究帕罗西汀联合奥氮平治疗对精神分裂症患者S100B、S100β及Repetin的影响。方法选取2016年2月—2017年4月本院治疗的精神分裂症患者80例,随机分为对照组和研究组,每组40例。对照组患者进行奥氮平单独治疗,研究组患者进行帕罗西汀联合奥氮平治疗,2组均治疗4周,比较2组患者治疗效果、PANSS评分,血清S100B、S100β及Repetin以及不良反应。结果治疗后,研究组总有效率明显高于对照组(χ~2=4.51,P=0.04);研究组PANSS评分下降程度明显优于对照组(F=2.98,P=0.02);研究组患者的血清学检查显示,研究组患者的S100B、S100β水平显著低于对照组,Repetin水平显著高于对照组;2组患者不良反应差异无统计学意义(P>0.05)。结论联合使用帕罗西汀和奥氮平对精神病患者的疗效显著,PANSS评分下降显著,血清S100B、S100β表达水平下显著降,Repetin水平明显上升,同时其安全性较高,值得临床推广。

Objective To observe the effect of paroxetine combined with olanzapine on S100B,S100βand Repetin in schizophrenic patients.Methods A total of 80 patients with severe acute pancreatitis in our hospital from February 2016 to April 2017 were randomly divided into control group and study group,with 40 cases in each group.The control group was treated with olanzapine alonea,and the study group was treated with paroxetine combined with olanzapine,the treatment was lasted for 4 weeks in two groups.The therapeutic effect,PANSS score,serum S100B,S100β,Repetin and adverse reactions between the two groups were observed.Results After treatment,the total response rate of the study group was significantly higher than that of the control group(χ2=4.51,P=0.04).The reduction in PANSS scores in the study group was significantly better than in the control group(F=2.98,P=0.02);Serological examination showed that S100B,S100βlevels were significantly lower,and Repetin levels was significantly higher than that in the control group,than the control group;The difference in adverse reactions between the two groups showed no statistically significant difference(P>0.05).Conclusion The combination of paroxetine and olanzapine has significant effect for schizophrenic patients.PANSS score is significantly decreased,levels of serum S100B and S100βexpression are significantly decreased,Repetin level is increased significantly,and it has higher safety.So it is worth promoting in clinic.