脑白质疏松与脑梗死的相关性及危险因素

Correlation between leukoaraiosis and cerebral infarction and risk factors

目的探讨脑白质疏松症(LA)与脑梗死的关系及脑白质疏松症发病的危险因素。方法选取脑梗死患者102例,根据是否并发脑白质疏松症将其分为LA组与非LA组,比较2组临床资料。结果 LA组中高血压病史10年以上、腔隙性梗死的患者数显著多于非LA组,超敏C反应蛋白(hs-CRP)、D二聚体(D-D)水平亦显著高于非LA组(P<0.05)。多因素Logistic回归分析显示,长期高血压病史、D-D增高是脑白质疏松症发病的独立危险因素。Spearman相关分析显示,脑白质疏松的严重程度与腔隙性脑梗死的数目具有正相关性。结论在脑梗死患者中,长期高血压病史、腔隙性脑梗死、高hs-CRP及D-D水平与并发脑白质疏松症密切相关。

Objective To explore the correlation between leukoaraiosis and cerebral infarction and the risk factors of leukoaraiosis(LA).Methods A total of 102 patients with cerebral infarction were divided into LA group and non LA group according to whether complicated with leukoaraiosis.Clinical data was compared between the two groups.Results In LA group,the numbers of patients with history of hypertension over ten years and with lacunar infarction were significantly higher than those in the non LA group,and the level of hs-CRP and D-D were significantly higher than non LA group(P<0.05).Multivariate Logistic regression analysis showed that long-term history of hypertension,high level of D-D were the risk factors of leukoaraiosis.Spearman correlation analysis showed that the severity of leukoaraiosis was positively correlated with the number of lacunar infarction.Conclusion In patients with cerebral infarction,long-term history of hypertensive,lacunar infarction,high levels of hs-CRP and D-D are closely related with leukoaraiosis.