不同剂量糖皮质激素治疗过敏性休克的疗效比较

Clinical effect of different doses of corticosteroids on the treatment of patients with allergic shock

目的探讨不同剂量的糖皮质激素治疗过敏性休克的临床效果。方法选取120例过敏性休克患者,采取随机数字表法分为低剂量组、中剂量组与高剂量组,每组40例。低剂量组给予100 mg的氢化可的松+250 mL的0.9%氯化钠溶液,中剂量组给予200 mg的氢化可的松+250 mL的0.9%氯化钠溶液,高剂量组给予300 mg的氢化可的松+250 mL的0.9%氯化钠溶液。比较3组临床疗效、症状缓解时间以及5 h内的尿量。结果 3组临床总有效率比较,差异有统计学意义(P<0.05)。3组神智恢复、血压恢复、呼吸频率恢复、心率恢复及皮疹消退时间比较,差异有统计学意义(P<0.05)。3组2、3、4、5 h的尿量比较,差异有统计学意义(P<0.05)。结论采用高剂量的氢化可的松治疗过敏性休克的临床疗效显著,能够缩短症状缓解时间。

Objective To explore the clinical effect of different doses of corticosteroids on the treatment of patients with allergic shock.Methods Totally 120 patients with allergic shock were randomly divided into low dose group,middle dose group and high dose group,40 cases in each group.Low dose group was treated with 100 mg of hydrocortisone plus 250 mL of 0.9%sodium chloride solution,the dose group was treated with 200 mg of hydrocortisone plus 250 mL of 0.9%sodium chloride solution,and high dose group was treated with 300 mg of hydrocortisone plus 250 mL of 0.9%sodium chloride solution.Clinical effect,symptom relief time and urine volume within 5 h were compared among three groups.Results There were significant differences in clinical total effective rate among three groups(P<0.05).There were significant differences in mental recovery,blood pressure recovery,respiratory rate recovery,heart rate recovery and rash subsiding time among three groups(P<0.05).In the comparison of urine volume at 2 h,3 h,4 h and 5 h,there were significant differences among three groups(P<0.05).Conclusion Application of high dose of hydrocortisone is effective in treatment of patients with allergic shock,which can shorten the recovery time of symptoms.