氨溴特罗联合孟鲁司特钠咀嚼片治疗儿童毛细支气管炎的疗效及对免疫学指标的影响

Effect of ambrocol combined with montelukast sodium chewable tablets on the treatment of children with bronchiolitis and its influence on the immunology indexes

目的探讨氨溴特罗联合孟鲁司特钠咀嚼片治疗儿童毛细支气管炎的疗效及对免疫学指标的影响。方法选择毛细支气管炎患儿136例,随机分为对照组68例(采用常规对症治疗、雾化吸入糖皮质激素与口服氨溴特罗治疗)与研究组68例(在对照组的基础上联合应用孟鲁司特钠咀嚼片治疗)。比较2组治疗1个疗程后的临床疗效、治疗前后免疫学指标的变化、临床症状与体征的消失时间以及药物不良反应。结果治疗1个疗程后,研究组总有效率为97.06%,显著高于对照组的86.76%(P<0.05);研究组免疫球蛋白E(Ig E)、白细胞介素-10(IL-10)、白细胞介素-4(IL-4)与嗜酸性粒细胞阳离子蛋白(ECP)均显著低于对照组(P<0.05),γ干扰素(INF-γ)与对照组对比差异无统计学意义(P<0.05);研究组咳嗽消失时间、发热消失时间、气喘消失时间、肺部干湿音消失时间均显著短于对照组(P<0.05);2组患儿治疗期间均未发现明显的药物不良反应。结论氨溴特罗联合孟鲁司特钠咀嚼片治疗儿童毛细支气管炎的效果满意,可以增强临床疗效,缩短病程,调节免疫学指标。

Objective To investigate the effect of ambrocol combined with montelukast sodium chewable tablets on the treatment of children with bronchiolitis and its influence on the indexes of immunology.Methods A total of 136 children with bronchiolitis were randomly divided into control group(n=68,treated with symptomatic therapy,inhaled corticosteroid and oral ambrocol therapy)and study group(n=68,treated with additional montelukast sodium chewable tablets on the basis of control group).The clinical efficacy,change of immunological indexes before and after treatment,disappearance time of clinical symptoms and signs,and adverse drug reactions were observed and compared between the two groups after one course of treatment.Results After one course of treatment,the total effective rate of study group was 97.06%,which was significantly higher than 86.76%of control group(P<0.05).In study group,the levels of IgE,IL-10,IL-4 and ECP were significantly lower than the control group(P<0.05),while there was no significant difference of INF-γbetween two groups(P<0.05).In the study group,the disappearance time of cough,fever disappeared time,disappearance time of asthma and disappeared time of lung dry rales were significantly shorter than the control group(P<0.05).No significant adverse reactions were observed between the two groups.Conclusion Ambrocol combined with montelukast sodium chewable tablets is effective in the treatment of children with bronchiolitis,which can enhance the clinical efficacy,shorten the course of disease and regulate the immunological indexes.