2型糖尿病患者血清游离脂肪酸水平与胰岛素抵抗的关系

Relationship between serum free fatty acids level and insulin resistance in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(T2DM)患者血清游离脂肪酸(FFA)水平与胰岛素抵抗(IR)的关系。方法选取106例T2DM患者为观察组,选择106例健康体检者为对照组,比较2组受检者体质量指数(BMI)、空腹血糖(FPG)、FFA、糖化血红蛋白(HbA1c)、总胆固醇(TG)、甘油三酯(TC)及胰岛素抵抗指数(HOMA-IR)水平。根据血糖控制水平将T2DM患者分为控制良好组(n=56)和控制不良组(n=50),比较2组患者FFA及HOMA-IR水平。分析T2DM患者血清FFA与HOMA-IR的相关性。结果观察组BMI、FPG、FFA、HbA1c、TC、TG、HOMA-IR均显著高于对照组(P<0.05);血糖控制不良组患者FFA及HOMA-IR水平均显著高于控制良好组(P<0.05);相关性分析显示,T2DM患者血清FFA与HOMA-IR水平呈正相关性(r=0.621,P<0.05)。结论血清游离脂肪酸水平与2型糖尿病患者胰岛素抵抗程度关系密切,且可以反映患者血糖控制水平。

Objective To investigate the relationship between serum free fatty acids(FFA)and insulin resistance(IR)in patients with type 2 diabetes mellitus(T2DM).Methods Totally 106 T2DM patients were selected as observation group,and 106 healthy people were selected as control group.Body mass index(BMI),FPG,FFA,HbA1c,TG,TC and HOMA-IR were compared between two groups.According to the blood glucose level,the T2DM patients were divided into good control group(n=56)and bad control group(n=50),and the FFA and HOMA-IR were compared two groups.Correlation between serum FFA and HOMA-IR in patients with T2DM was analyzed.Results In the observation group,BMI,FPG,FFA,HbA1C,TC,TG and HOMA-IR were significantly higher than the control group(P<0.05).FFA and HOMA-IR in bad control group were significantly higher than the good control group(P<0.05).Correlation analysis showed that serum FFA was positively correlated with HOMA-IR level in T2DM patients(r=0.621,P<0.05).Conclusion Serum free fatty acids level is closely related to insulin resistance in patients with T2DM,which can reflect the blood glucose control level.