老年高血压合并高同型半胱氨酸血症与骨代谢指标的关系研究

Correlation between bone mineral density and serum osteocalcin in elderly patients with hypertension complicated by high hyperhomocysteinemia

目的研究老年高血压合并高同型半胱氨酸血症(HHcy)与骨代谢指标骨密度(BMD)、血清骨钙素(BGP)的相关性。方法选择接受治疗的高血压合并HHcy老年患者85例为观察组。然后同期选择老年健康志愿者50例为对照组。比较2组血压、Hcy、血脂以及骨代谢指标,然后进行相关性分析。结果观察组收缩压、收缩压、Hcy水平、TC、TG及LDL水平均显著高于对照组,而HDL水平显著低于对照组。2组女性BMD水平均显著低于男性,而BGP水平高于男性。观察组BMD总体水平低于男性,BGP总体水平显著高于男性,差异均有统计学意义(P均<0.05)。高血压合并HHcy患者中骨代谢指标中的BMD与收缩压、舒张压、Hcy、TC、TG以及LDL呈现显著负相关,与HDL呈现显著正相关。而骨代谢指标BGP与收缩压、舒张压、Hcy、TC、TG以及LDL呈现显著正相关,与HDL呈现显著负相关。结论高血压合并HHcy老年患者可能与BMD升高、BGP降低有关,与骨质疏松的发生存在密切的相关性,临床上需要引起重视。

Objective To investigate the correlation between bone mineral density(BMD)and serum osteocalcin(BGP)in elderly patients with hypertension complicated by high hyperhomocysteinemia(HHcy).Methods Eighty-five elderly patients with hypertension complicated by HHcy who were treated in our hospital from July 2012 to December 2015 were enrolled as observation group.At the same time,50 elderly healthy volunteers were enrolled as control group.The blood pressure,Hcy levels,blood lipid and bone metabolism indexes were observed and compared between the two groups,moreover,the correlation was analyzed.Results The systolic blood pressure,systolic blood pressure,Hcy levels,TC,TG and LDL levels in observation group were significantly higher than those in control group,however,the HDL levels were significantly lower than those in control group.Moreover the BMD levels of females were significantly lower than those of males in both groups(P<0.05),however,the BGP levels of females were significantly higher than those of males.In addition the total BMD levels of females in observation group were significantly lower than those of males,however the total BGP levels of females were significantly higher than those of males(P<0.05).Besides the bone metabolism indexes in observation group were closely correlated with systolic blood pressure,diastolic blood pressure,Hcy,TC,TG and LDL,however,which were positively correlated with HDL.Conclusion The elderly patients with hypertension complicated by HHcy may be associated with increase of BMD and decrease of BGP,moreover,which has close correlation with the incidence of osteoporosis,therefor,it should be paid much attention in clinical practice.