循证护理干预对急性白血病患者化疗后口腔感染和免疫系统的影响

Application of evidence-based nursing intervention in oral infection and immune system in patients with acute leukemia after chemotherapy

目的探讨循证护理干预对急性白血病患者化疗后口腔感染的预防效果以及对免疫系统的影响。方法选取化疗的急性白血病患者112例作为研究对象,根据随机数表法均分为2组。对照组给予常规护理,观察组在常规护理基础上实施循证护理模式,对比2组患者护理后口腔感染发生率、护理前后免疫系统变化及心理状况评分。结果观察组患者口腔溃疡发生率低于对照组(P<0.05);护理前,2组患者免疫系统及心理状况评分差异无统计学意义(P>0.05);护理后,观察组患者CD_3~及CD_3~CD_8~水平均高于对照组(P<0.05),且观察组SAS及SDS评分均低于对照组(P<0.05)。结论循证护理干预可有效预防急性白血病患者化疗后出现的口腔感染,降低口腔溃疡发生率,同时有利于提高患者免疫功能,促进预后恢复。

Objective To study the application of evidence-based nursing intervention in oral infection and immune system after chemotherapy in patients with acute leukemia.Methods A total of 112 patients with acute leukemia underwent chemotherapy in our hospital were divided into two groups according to random number table method.The patients in the control group were given routine care,and the patients in observation group were given evidence-based nursing intervention on the basis of routine nursing.The incidence of oral infection,the changes of immune system before and after nursing and scores of psychological status were observed and compared between two groups.Results The observation group had lower incidence of oral ulcer than the control group(P<0.05).Before nursing,there was no significant difference in the scores of immune system and psychological status between the two groups(P>0.05).After nursing,the levels of CD 3+and CD 3+CD 8+in the observation group were significantly higher,and SAS and SDS scores were lower than that in the control group(P<0.05).Conclusion Evidence-based nursing intervention can effectively prevent oral infection after chemotherapy in patients with acute leukemia and reduce the incidence of oral ulcer,and improve patients′immune function and promote prognosis.