硝酸异山梨酯注射液联合多巴胺治疗慢性心衰的临床疗效分析

Analysis of Clinical Curative Effect of Isosorbide Dinitrate Injection Combined with Dopamine in Treatment of Chronic Heart Failure

目的分析硝酸异山梨酯注射液联合多巴胺在慢性心衰中的临床疗效。方法选取2015年6月—2017年5月160例医院收治慢性心衰患者作为观察对象,随机分为观察组与对照组,每组80例。对照组采用单药硝酸异山梨酯注射液治疗,观察组则在对照组的基础上加入多巴胺治疗。观察两组患者的临床疗效差异,并比较两组治疗前后心功能指标的变化,同时记录两组患者的不良反应发生率。结果观察组治疗后纵有效率为91.3%,高于对照组81.3%(χ2=5.635,P<0.05);2组治疗前LA、LVEDD、LVESD、LVEF及E/A水平比较差异无统计学意义(t=0.195,1.212,0.682,2.105,1.551,P>0.05);观察组治疗后LA(30.45±6.23)mm、LVEDD(42.56±3.34)mm、LVESD(29.46±1.76)mm,低于对照组(t=14.835,16.298,15.332,P<0.05);观察组治疗后LVEF(65.54±1.21)%及E/A水平(1.46±0.34),均高于对照组(t=19.846,15.683,P<0.05);两组治疗期间均无明显不良反应发生。结论硝酸异山梨酯注射液联合多巴胺在慢性心衰中具有较好的临床疗效,能够有效缓解患者的临床症状,从而改善生活质量,值得在临床中推广使用。

Objective To analyze the clinical curative effect of isosorbide dinitrate injection combined with dopamine in treatment of chronic heart failure.Methods 160 cases of patients with chronic heart failure in our hospital from June 2015 to May 2017 were selected and randomly divided into two groups with 80 cases in each,the control group were treated with isosorbide dinitrate injection,while the observation group were treated with isosorbide dinitrate injection combined with dopamine,and the clinical curative effect of patients was observed,and the heart function index of the two groups before and after treatment was compared,and the incidence rate of adverse reactions of the two groups was recorded.Results After treatment,the total effective rate in the observation group was higher than that in the control group(91.3%vs 81.3%)(χ2=5.635,P<0.05);and the differences in the LA,LVEDD,LVESD,LVEF and E/A levels before treatment between the two groups were not statistical significance(t=0.195,1.212,0.682,2.105,1.551,all P>0.05);after treatment,the LA,LVEDD and LVESD in the observation group were respectively(30.45±6.23)mm,(42.56±3.34)mm,(29.46±1.76)mm,which were lower than those in the control group(t=14.835,16.298,15.332,all P<0.05);after treatment,the LVEF and E/A levels in the observation group were respectively(65.54±1.21)%and(1.46±0.34),which were higher than those in the control group(t=19.846,15.683,all P<0.05),and there were no obvious adverse reactions in the two groups during treatment.Conclusion The clinical curative effect of isosorbide dinitrate injection combined with dopamine in treatment of chronic heart failure is better,which can effectively relieve the clinical symptoms thus improving the quality of life,and it is worth clinical promotion and application.