艾司西酞普兰与帕罗西汀治疗老年性抑郁症对比分析

Comparative Analysis of Escitalopram and Paroxetine in Treatment of Senile Depression

目的研究艾司西酞普兰、帕罗西汀治疗老年性抑郁症的效果。方法在该院2015年2月—2017年1月收治的老年抑郁症患者中选出60例随机分组,A组患者给予艾司西酞普兰治疗,B组患者给予帕罗西汀治疗,对比两组患者的治疗效果。结果 (1)A组在治疗2、4、8周后,其HADM评分分别变为(15.10±0.65)分、(12.28±0.54)分、(7.46±0.32)分,B组为(18.46±1.05)分,(15.47±0.75)分,(10.27±0.57)分,经数据分析,差异有统计学意义(P<0.05);(2)A组发生不良反应发生率是13.33%,较B组的不良反应发生率低出约27.00%,经数据分析,差异有统计学意义(P<0.05);(3)A组在治疗2、4、8周后,以第8周为例,其工作/学习、社交生活、家庭生活/家庭责任的评分分别是(2.11±0.15)分、(2.03±0.21)分、(1.67±0.20)分,B组为(2.89±0.18)分,(2.56±0.23)分,(2.38±0.28)分,经数据分析,差异有统计学意义(P<0.05)。结论在老年性抑郁症的治疗中应用艾司西酞普兰治疗效果确切,有助于促进患者社会功能的恢复,且安全性高,值得推广。

Objective To research the effect of escitalopram and paroxetine in treatment of senile depression.Methods 60 cases of senile depression patients admitted and treated in our hospital from February 2015 to January 2017 were randomly divided into two groups,the group A were treated with escitalopram,while the group B were treated with paroxetine,and the treatment effect was compared between the two groups.Results After the two-week,four-week and 8-week treatment,the HADM scores were respectively(15.10±0.65)points,(12.28±0.54)points,(7.46±0.32)points in the group A,which were about(18.46±1.05)points,(15.47±0.75)points,(10.27±0.57)points in the group B,and the differences were statistically significant(P<0.05);the incidence rate of adverse reactions in the group A was 13.33%,which was about 27.00%lower than that in the group B,and the difference was statistically significant(P<0.05);the work/study,social life,family life/family responsibility in the two-week,four-week and 8-week treatment in the group A were respectively(2.11±0.15)points,(2.03±0.21)points,(1.67±0.20)points,which were about(2.89±0.18)points,(2.56±0.23)points,(2.38±0.28)points in the group B,and the differences were statistically significant,(P<0.05).Conclusion The application effect of escitalopram in treatment of senile depression is definite,which contributes to promoting the recovery of social function with high safety,and it is worth promotion.