米索前列醇与小剂量缩宫素对足月妊娠引产的临床疗效对比

Comparison of Clinical Curative Effect of Misoprostol and Small-dose Oxytocin for Full-term Labor Induction

目的探究并全面分析米索前列醇与小剂量缩宫素对足月妊娠引产的临床疗效对比。方法于2015年1月—2017年1月在该院接受治疗的足月妊娠引产产妇中选取44例作为研究对象,采用分段随机法将其均分为对照组(n=22例)、实验组(n=22例),对照组产妇采用小剂量缩宫素进行引产,而实验组产妇则采用米索前列醇进行引产,观察并对比两组的用药前、后的宫颈成熟度,分娩时的指标以及临床治疗的效果。结果用药前,两组产妇的宫颈成熟度差异无统计学意义(P>0.05);用药后,实验组产妇的宫颈成熟度Bishop(5.63±2.24)分明显高于对照组(4.62±1.73)分,差异有统计学意义(P<0.05);在用药后,实验组产妇临产时间、宫缩始动时间、产程时间分别为(5.20±1.10)、(3.00±1.15)、(6.75±2.03)h,而对照组的分别为(8.30±3.15)、(5.48±1.70)、(9.92±2.42)h,实验组的分娩指标与对照组对比均明显缩短(P<0.05);且实验组引产的总有效率为86.36%,对照组引产的总有效率则为54.55%,实验组引产总有效率显著优于对照组,差异有统计学意义(P<0.05);对比两组新生儿的结局,差异无统计学意义(P>0.05)。结论采用米索前列醇对足月妊娠产妇进行引产,无论是临产时间、宫缩时间还是产程均比采用小剂量缩宫素要短,且有效将自然分娩率提高,值得在临床上广泛应用。

Objective To study and comprehensively analyze the clinical curative effect of misoprostol and small-dose oxytocin for full-term labor induction.Methods 44 cases of full-tem labor induction delivery women treated in our hospital from January 2015 to January 2017 were selected as the research objects and randomly divided into two groups with 22 cases in each,the control group adopted the small-dose oxytocin,while the experimental group adopted the misoprostol,and the cervix mature degree before and after medication,delivery indexes and clinical treatment effect were observed and compared.Results Before medication,the difference in the cervix mature degree between the two groups was not obvious,the difference was statistically significant(P<0.05),after medication,the cervix mature degree Bishop in the experimental group was obviously higher than that in the control group[(5.63±2.24)points vs(4.62±1.73)points](P<0.05),after medication,the labor time,initial contraction time and labor course time in the experimental group and in the control group were respectively(5.20±1.10)h,(3.00±1.15)h,(6.75±2.03)h and(8.30±3.15)h,(5.48±1.70)h,(9.92±2.42)h,and the delivery index in the experimental group was obviously shortened compared with that in the control group,the difference was statistically significant(P<0.05),and the total labor induction effective rate in the experimental group and in the control group was respectively 86.36%and 54.55%,and the total labor induction effective rate in the experimental group was obviously better than that in the control group,and the difference was statistically significant(P<0.05),and the difference in the newborns outcome between the two groups was not statistically significant(P>0.05).Conclusion The labor time,oxytocin time and labor course of misoprostol for full-term labor induction are shorter than those of small-dose oxytocin,which can effectively improve the natural delivery rate,and it is worth clinical application.