BNP、NT-proBNP、肌钙蛋白在新生儿心血管疾病中的研究进展

Research Progress of BNP, NT-proBNP and Troponin in the Angiocardiopathy of Newborns

心力衰竭是新生儿各种心血管疾病的最终结局,其病因复杂,症状多种多样,临床表现不典型,早期诊断有一定困难。当临床症状明显出现时,多数患儿已失去最佳干预时期,因此在心衰的早期阶段寻找合适的生物学标志物是诊断及治疗的关键。目前国内外对新生儿心力衰竭疾病的诊断仍缺乏金标准,大多限于临床症状、体征的判断。许多生物学标志物参与新生儿心血管疾病的发生发展过程中,所以研究诊断价值较高的生物学标志物,可以早期发现并且在合适的时期积极干预疾病的病理生理过程,对新生儿预后具有重要意义。该文主要阐述BNP、NT-proBNP、肌钙蛋白(cTn)在新生儿心血管疾病中的研究进展。

The heart failure is a final outcome of various cardiovascular diseases of newborns,the causes are complex and the symptoms are multiple,and the clinical manifestations are atypical,and the early diagnosis has a certain difficulties,most children had lost the best intervention period when the clinical symptoms occur,therefore,hunting for the suitable biochemical markers in early phrase of heart failure is the key to diagnosis and treatment,currently,the diagnosis of heart failure diseases still lacks the golden standards,most are limited to the determination of clinical symptoms and vital signs,therefore,researching the biochemical markers with high diagnosis value can early discover diseases and actively intervene in the pathological and physical course of diseases,and it is of important significance to the prognosis of newborns.The paper mainly elaborates the research progress of BNP,NT-proBNP and troponin in the angiocardiopathy of newborns.