促红细胞生成素与肥胖

Erythropoietin and Obesity

促红细胞生成素(Erythropoietin,EPO)是一种分子量为30.4k Da的肾源生长因子,其作用在于控制细胞增殖、免疫调控、代谢平衡、血管功能以及细胞保护。EPO被用于研究多种疾病的治疗,其中对于代谢疾病尤其是肥胖治疗的研究是近年来研究的热点。肥胖发病率的高发是目前世界性的流行病,其发病可导致残疾甚至死亡的产生。除了治疗贫血,EPO能够改善肥胖病人的心血管功能并减少疲劳、改善认知功能,同时也能调控细胞能量代谢、组织修复再生、凋亡、自噬等。

Erythropoietin(EPO)is a 30.4 kDa kidney-derived growth factor.Its role is to control cell proliferation,immune regulation,metabolic balance,vascular function,and cell protection.In recent yearsEPO is used to the treatment of various diseases,and be researched as treatment of metabolic diseases,especially obesity treatment.The high incidence of obesity is currently a worldwide epidemic,and its onset can lead to disability or even death.In addition to the treatment of anemia,EPO can improve cardiovascular function in obese patients and reduce fatigue,improve cognitive function,but also can regulate cell energy metabolism,tissue repair regeneration,apoptosis,autophagy.