卵巢移位术对宫颈癌患者卵巢功能、卵巢血流及性生活质量的影响研究

Effects of ovarian transposition on ovarian function, ovarian blood flow and quality of life in patients with cervical cancer

目的分析宫颈癌患者行卵巢移位术对其卵巢功能、血流以及性生活质量的影响。方法回顾性分析2015年1月至2016年1月于本院就诊的114例宫颈癌患者的临床资料,将无需行卵巢移位术者纳入对照组(38例),需行卵巢移位术者纳入观察组(76例),并将术后未行放疗者设为观察1组(38例),术后予以放疗者设为观察2组(38例),比较各组患者术后卵巢功能、卵巢血流情况、性生活质量及并发症发生情况。结果术前,观察1组、观察2组及对照组患者孕酮(progesterone,P)、雌二醇(estradiol,E_2)、促黄体生成素(luteinizing hormone,LH)及促卵泡成熟激素(follicle-stimulating hormone,FSH)、卵巢动脉血流参数比较差异均无显著性(P>0.05)。术后,对照组与观察1组患者P、E_2、LH、FSH、卵巢动脉血流参数比较差异均无显著性(P>0.05),观察2组患者术后随访12个月,P、E_2、LH及FSH水平与对照组和观察1组比较差异均具有显著性(P<0.05);术后,观察2组患者阻力指数(resistance index,RI)高于观察1组和对照组(P<0.05),观察1组和观察2组患者女性性功能指数(female sexual function index,FSFI)均明显高于对照组(P<0.05),且观察2组患者FSFI评分低于观察1组(P<0.05)。观察组1组和观察2组患者并发症发生率均显著高于对照组(P<0.05)。结论宫颈癌患者行卵巢移位术后仍可保留卵巢功能,性生活质量显著提高,但患者术后易并发腹痛;卵巢移位术后放疗s可对患者卵巢功能和性生活质量造成影响。

Objective To study the ovarian function,blood flow and quality of life in patients with cervical cancer after ovarian transposition.Method From January 2015 to January 2016,114 patients with cervical cancer clinical data were retrospectively analyzed,the control group patients(38 cases)no need to be treated with ovarian transposition,the observation group patients need to be treated with ovarian transpositior,no postoperative radiotherapy as observation group 1(38 cases),postoperative to radiotherapy as observation group 2(38 cases),postoperative ovarian function,ovarian blood flow and sexual life quality and complications between two groups were compared.Result Before operation,there were no significant differences in P,E2,LH and FSH of ovarian function index among each groups(P>0.05),there were no significant differences between control group and observation group 1 after operation(P>0.05).After 12 months of follow-up,the index of ovarian function in observation group 2 was significantly changed,compared with the other two groups,the difference was significant(P<0.05).Before operation,there was no significant difference in hemodynamic indexes among each group(P<0.05).After treatment,the observation group 2 of RI were significance higher than control group and observation group 1(P<0.05).The quality of life in observation group was significantly higher than that of control group,and sexual life index score low sense in observation group 2 were significance lower than that of observation group 1(P<0.05).In addition,the incidence of complications in each group were compared,and the observation group 1 and observation group 2 were higher than those in control group(P<0.05).Conclusion Cervical cancer patients after ovarian transposition can still preserving ovarian function and sexual life quality also increased significantly,but the postoperative patients complicated with abdominal pain,without functional ovarian cysts;radiotherapy after ovarian transposition affects ovarian function and quality of life.