贝那普利与前列地尔联合治疗糖尿病肾病蛋白尿的临床效果

Clinical effect of benazepril combined with alprostadil in treating diabetic nephropathy with proteinuria

目的分析贝那普利与前列地尔联合治疗糖尿病肾病蛋白尿的临床效果。方法选取2016年1月至2016年12月入院的84例糖尿病肾病蛋白尿患者,按照治疗方式将其分为研究组和对照组,各42例。对照组行贝那普利治疗,研究组行贝那普利与前列地尔联合治疗。比较两组的治疗总有效率、不良发生率、24 h尿蛋白及24 h尿白蛋白水平。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,两组的24 h尿蛋白、24 h尿白蛋白水平均降低,且研究组低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论前列地尔与贝那普利联合应用于糖尿病肾病蛋白尿治疗中具有显著效果,值得推广应用。

Objective To analyze the clinical effect of benazepril combined with alprostadil in treating diabetic nephropathy with proteinuria.Methods Eighty-four patients undergoing diabetic nephropathy with proteinuria admitted from January 2016 to December 2016 were selected and divided into study group and control group according to the treatment methods,with 42 cases in each group.The control group received benazepril treatment and the study group received combination therapy with benazepril and alprostadil.The total effective rate,the incidence of adverse reactions,24 h urine protein and 24 h urinary albumin levels were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group(P<0.05).After treatment,the levels of 24 h urine protein and 24 h urinary albumin decreased in both groups,and those of the study group were lower than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Benazepril combined with alprostadil in treating diabetic nephropathy with proteinuria has a significant effect,which is worth promotion and application.