孟鲁司特钠治疗哮喘-慢阻肺重叠综合征的效果

Effect of montelukast sodium in the treatment of asthma COPD overlap syndrome

目的探讨孟鲁司特钠治疗哮喘-慢阻肺重叠综合征的临床效果。方法将257例哮喘-慢阻肺重叠综合征患者依其意愿分为观察组(135例)与参考组(122例),分别行常规治疗与常规治疗+孟鲁斯特钠治疗,观察两组患者治疗前、后的呼吸困难指数、CAT、ACT评分、肺功能变化及1年内复发率。结果治疗后,两组患者的呼吸困难指数分级均改善,且观察组优于参考组(P<0.05)。治疗后,两组患者的CAT评分均下降,ACT评分、FEV_1%、FEV_1/FVC均上升,且观察组均优于参考组(P<0.05)。观察组随访1年的复发率明显低于参考组(P<0.05)。结论孟鲁司特钠在哮喘-慢阻肺重叠综合征患者的治疗中能够快速提高患者呼吸功能,促进肺通气改善,具有显著应用价值。

Objective To investigate the clinical effect of montelukast sodium in the treatment of asthma COPD overlap syndrome.Methods A total of 257 patients with asthma COPD overlap syndrome were divided into the observation group(135 cases)and the reference group(122 cases)according to their wishes,and given routine treatment and routine treatment combined with montelukast sodium.The dyspnea indexes,CAT,ACT scores,pulmonary function change and recurrence rate within 1 year were observed before and after treatment in the two groups.Results After treatment,the grade of dyspnea indexes in the two groups improved,and those in the observation group were better than the reference group(P<0.05).After treatment,the CAT scores decreased and ACT scores,FEV1%and FEV1/FVC increased in the two groups,and those in the observation group were better than the reference group(P<0.05).Following-up for 1 year,the recurrence rate in the observation group was significantly lower than that in the reference group(P<0.05).Conclusion Montelukast sodium in the treatment of asthma COPD overlap syndrome can improve the respiratory function and promote the pulmonary ventilation,which has significant value of application.