大剂量奥美拉唑治疗老年胃溃疡合并出血的临床疗效

Clinical efficacy of high-dose omeprazole in the treatment of elderly patients with gastric ulcer complicated with hemorrhage

目的分析大剂量奥美拉唑治疗老年胃溃疡合并出血的临床疗效。方法选择本院2015年10月至2017年10月收治的94例老年胃溃疡合并出血患者为研究对象,根据入院时间分为A组和B组,各47例。两组均给予奥美拉唑治疗,A组给予大剂量治疗,B组给予常规剂量治疗。比较两组临床疗效、再出血率及不良反应发生情况。结果 A组的治疗总有效率高于B组(P<0.05);A组治疗3 d内及1、3个月内的再出血率分别为6.38%、2.13%、0.00%,均低于B组的21.28%、14.89%、12.77%(P<0.05);两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论大剂量奥美拉唑治疗老年胃溃疡合并出血可显著降低再出血率,并发症较少,可作为该病的常规疗法积极推广。

Objective To analyze the clinical curative effect of high-dose omeprazole in the treatment of elderly patients with gastric ulcer complicated with hemorrhage.Methods A total of 94 elderly patients with gastric ulcer complicated with hemorrhage admitted in our hospital from October 2015 to October 2017 were selected and divided into group A and group B according to the admission order,with 47 cases in each group.Both groups were given omeprazole treatment,group A used high-dose treatment,group B used conventional dose therapy.The clinical efficacy,re-bleeding rates and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the group A was higher than that of the group B(P<0.05).The re-bleeding rates of the group A treatment within 3 d and within 1,3 months were 6.38%,2.13%and 0.00%respectively,which were lower than 21.28%,14.89%,12.77%of the group B,the differences were statistically significant(P<0.05).There was no significant difference in the total incidences of complications between the two groups(P>0.05).Conclusion High-dose omeprazole treatment in elderly patients with gastric ulcer complicated with bleeding can significantly reduce the re-bleeding rate,with less complications.It can be actively promoted as a routine treatment of the disease.