老年人群维生素B_(12)和叶酸水平是否对轻度认知功能障碍(MCI)和阿尔兹海默症(AD)患者存在潜在影响分析

Analysis of Whether the Vitamin B_(12) and Folic Acid Levels Have a Potential Effect on the MCI and AD Senile Patients or not

目的观察对于轻度认知功能障碍(MCI)和阿尔兹海默症(AD)的老年人群检测维生素B_(12)和叶酸水平影响分析。方法将该院2015年10月—2017年10月收治的67例MCI患者为MCI组,41例AD患者为AD组,78名健康体检者为正常组。将3组患者基本资料,维生素B_(12)和叶酸水平分析。结果维生素B_12、叶酸水平及CMMSE评分成正比,其中最高为正常组,分别为(658.15±373.37)pg/mL、(9.29±3.46)ng/mL、(83.6±16.50)分;最低为AD组,分别为(502.36±313.37)pg/mL、(7.82±4.18)ng/mL、(41.9±19.90)分,3组组间相比差异有统计学意义(P<0.01)。结论通过对老年人维生素B_(12)和叶酸水平的检测,可预测是否为轻度认知障碍与阿尔兹海默症的潜在患者。

Objective To observe the whether the vitamin B12 and folic acid levels have a potential effect on the MCI and AD senile patients.Methods 67 cases of MCI patients admitted and treated in our hospital from October 2015 to October 2017 were selected as the MCI group,and 41 cases of AD patients were used as the AD group,and 78 cases of healthy physical examination group were used as the normal group,and the basic information,vitamin B12 and folic acid level were analyzed.Results The vitamin B12 and folic acid levels were positive correlated with the CMMSE scores,and the levels in the normal group were the highest,respectively(658.15±373.37)pg/mL,(9.29±3.46)ng/mL,(83.6±16.50)points,and the levels in the AD group were the lowest,respectively(502.36±313.37)pg/mL,(7.82±4.18)ng/mL,(41.9±19.90)points,and the differences were statistically significant(P<0.01).Conclusion The test of vitamin B12 and folic acid levels of senile people can predict whether the patients are with MCI and AD.