慢性阻塞性肺疾病急性加重期患者外周血嗜酸性粒细胞水平变化及临床意义

Changes of Peripheral Blood Eosinophil Cell Level of Patients with Acute Exacerbation Chronic Obstructive Pulmonary Disease and Clinical Significance

目的分析慢性阻塞性肺疾病急性加重期外周血嗜酸性粒细胞水平(EOS%)变化及临床意义。方法统计该院在2015年1月—2016年12月收治的146例慢性阻塞性肺疾病急性加重期患者的临床资料、外周血嗜酸性粒细胞百分比、住院时间、D-二聚体、C-反应蛋白、中性粒细胞/淋巴细胞比值、再次住院、死亡率等,根据嗜酸性粒细胞水平将146例研究对象分为两组,A组EOS%≤2%,B组EOS%>2%。分析两组在临床资料、外周血嗜酸性粒细胞百分比、住院时间、C-反应蛋白、中性粒细胞/淋巴细胞比值、再次住院等方面的差异。结果 A组EOS(1.49±0.33)%、NLR(5.77±2.03)、CRP(36.89±4.73)mg/L与B组EOS(3.59±0.42)%、NLR(3.95±1.12)、CRP(22.14±2.17)mg/L相比差异有统计学意义(P<0.05),两组死亡率差异无统计学意义(P>0.05),A组再住院例率(61.22%)明显高于B组再住院率(39.58%),差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性加重期外周血嗜酸性粒细胞水平发生明显变化,可将外周血嗜酸性粒细胞水平作为判断该疾病诊断、预后、指导临床治疗的一种生物学指标。

Objective To analyze the changes of peripheral blood eosinophil cell level of patients with acute exacerbation chronic obstructive pulmonary disease and clinical significance.Methods The clinical data and percentage of peripheral blood eosinophil cell,length of stay,D-dimer,C-reactive protein,neutrophile granulocyte/lymphocyte ratio,second hospitalization,and morality in our hospital from January 2015 to December 2016 were counted,and 146 cases of patients were divided into two groups according to the eosinophile granulocyte level,including EOS%≤2%in the group A and EOS%>2%in the group B,and the clinical data,percentage of peripheral blood eosinophil cells,length of stay,C-reactive protein,neutrophile granulocyte/lymphocyte ratio and second hospitalization of the two groups were analyzed.Results The differences in the EOS,NLR,CRP between the group A and the group B were statistically significant[(1.49±0.33)%,(5.77±2.03),(36.89±4.73)mg/L vs(3.59±0.42)%,(3.95±1.12),(22.14±2.17mg/L)](P<0.05),and the difference in the morality between the two groups was not obvious(P>0.05),and the hospitalization case in the group A was obviously higher than that in the group B(61.22%vs 39.58%),and the difference was statistically significant(P<0.05).Conclusion The change of peripheral blood eosinophil cell level of patients with acute exacerbation chronic obstructive pulmonary disease and clinical significance is obvious,which can be used a kind of biochemical index of determining the disease diagnosis,prognosis and guiding the clinical treatment.