高血压患者合并高血脂联合降脂对降低心脑血管事件发生的分析

Analysis of Lipid Lowering in Reducing the Occurrence of Cardiovascular Events of Patients with Hypertension and Hyperlipemia

目的观察高血压患者合并高血脂联合降脂对降低心脑血管事件发生情况。方法选取2015年12月—2016年12月该院治疗的高血压合并高血脂患者211例,按照随机对患者分组的原则将该次观察的患者分成两组,治疗组(n=118)采取6.25~12.5 mg/d氢氯噻嗪,75 mg/d卡托普利,10~20 mg/d辛伐他汀治疗的方法,给予对照组(n=93)采取6.25~12.5 mg/d氢氯噻嗪,75 mg/d卡托普利治疗的方法 ,对两组患者的血压、血脂及1年内心脑血管事件的发生事件进行观察。结果治疗组患者和对照组患者治疗前收缩压、舒张压差异无统计学意义,治疗组患者治疗前及治疗后0.5、1、2、4、8、12个月收缩压分别是(167.22±11.61)、(148.18±13.78)、(139.82±11.27)、(138.10±10.18)、(137.55±9.28)、(137.81±8.06)、(136.02±8.43)mm Hg,舒张压分别是(95.33±8.78)、(88.57±7.07)、(87.74±7.02)、(86.54±7.57)、(85.72±7.12)、(86.02±6.48)、(86.22±6.36)mm Hg;对照组患者治疗前及治疗后0.5、1、2、4、8、12个月收缩压分别是(165.86±12.28)、(147.94±13.02)、(138.75±12.08)、(139.56±11.27)、(138.98±9.84)、(136.85±9.08)、(136.80±9.17)mm Hg,舒张压分别是(97.21±9.08)、(89.44±7.77)、(88.48±7.94)(87.12±7.65)、(87.38±6.90)、(86.32±7.22)、(86.80±7.01)mm Hg。经过治疗后对比两组患者血压情况,发现血压均已稳定下降,两组之间差异无统计学意义(P>0.05)。两组患者血脂治疗前差异无统计学意义,经过实施治疗6、12个月后,治疗组患者TG、LDL-C、HDL-C分别是(148.57±32.04)、(126.75±32.29)、(42.58±10.19)mg/d L和(139.43±24.22)、(108.58±26.55)、(44.59±8.65)mg/d L。对照组患者(165.33±28.39)、(139.76±33.69)、(39.48±6.41)mg/d L和(162.25±26.29)、(138.29±28.55)、(39.90±8.43)mg/d L。在血脂各项指标变化上,治疗组患者有着显著的改善,两组之间差异有统计学意义(P<0.05)。经过治疗后,治疗组患者的心脑血管事件的发生率为7.6%,对照组患者的心脑血管事件的发生率为18.3%,对比对照组患者的心脑血管事件的发生显著要少(P<0.05)。结论采取降脂治疗高血压合并高血脂患者,能够将心脑血管事件的发生率得到显著的降低,对患者生活质量的提高也有着非常大的帮助,因此采取此种方式实施治疗具有非常重要的积极作用。

bjective To observe the lipid lowering in reducing the occurrence of cardiovascular events of patients with hypertension and hyperlipemia.Methods 211 cases of patients with hypertension and hyperlipemia treated in our hospital from December 2015 to December 2016 were selected and randomly divided into two group,the treatment group with 118 cases used the 6.25~12.5 mg/d hydrochlorothiazide,75 mg/d captopril and 10~20 mg/d simvastatin,while the control group with 93 cases used the 6.25~12.5 mg/d hydrochlorothiazide,75 mg/d captopril,and the blood pressure,blood liquid and occurrence of 1-year cardiovascular events of the two groups were observed.Results There were obvious differences in the systolic pressure and diastolic pressure between the two groups before treatment,and the systolic pressures and diastolic pressures in 0.5 months,1 month,2 months,4 months,8 months and 12 months before and after treatment in the treatment group and in the control group were respectively(167.22±11.61),(148.18±13.78),(139.82±11.27),(138.10±10.18),(137.55±9.28),(137.81±8.06),(136.02±8.43)mmHg,and(95.33±8.78),(88.57±7.07),(87.74±7.02),(86.54±7.57),(85.72±7.12),(86.02±6.48),(86.22±6.36)mmHg and(165.86±12.28),(147.94±13.02),(138.75±12.08),(139.56±11.27),(138.98±9.84),(136.85±9.08),(136.80±9.17)mmHg,and(97.21±9.08),(89.44±7.77),(88.48±7.94),(87.12±7.65),(87.38±6.90),(86.32±7.22),(86.80±7.01)mmHg,after treatment,the blood pressure was compared between the two groups,and the blood pressure steadily decreased,and the difference between the two groups was obvious(P>0.05),and the difference in the blood liquid between the two groups was obvious,after 6-month and 12-month treatment,the TG,LDL-C,HDL-C levels in the treatment group and in the control group were respectively(148.57±32.04),(126.75±32.29),(42.58±10.19)mg/dL,and(139.43±24.22),(108.58±26.55),(44.59±8.65)mg/dL and(165.33±28.39),(139.76±33.69),(39.48±6.41)mg/dL,and(162.25±26.29),(138.29±28.55),(39.90±8.43)mg/dL,and various indicators of blood liquid in the treatment were obviously improved,and the differences were obvious(P<0.05),after treatment,the incidence rate of cardiovascular events in the treatment group were obviously lower than those in the control group(P<0.05).Conclusion The lipid lowering in treatment of patients with hypertension and hyperlipemia can obviously decrease the incidence rate of cardiovascular events,which is of greatly help to the improvement of quality of life,therefore,it is of very important significance.