红花注射液联合小牛血清去蛋白治疗Ⅱ型糖尿病周围神经病变的疗效观察

Therapeutic effect of Safflower injection combined with Deproteinised calf blood serum on type Ⅱ diabetic peripheral neuropathy

目的探讨应用红花注射液联合小牛血清去蛋白治疗Ⅱ型糖尿病周围神经病变(DPN)的临床效果。方法选取2016年1月至2017年1月收治的104例Ⅱ型DPN患者,采取前瞻性随机对照的形式将其随机分成治疗组(n=52)与对照组(n=52)。两组均给予一致的基础治疗,对照组在此基础上予以小牛血清去蛋白注射液治疗,治疗组在对照组基础上加用红花注射液治疗。记录比较两组治疗前后神经传导速度、血液流变学指标、血糖[空腹血糖(FBG)、餐后2 h血糖(PBG)]、血脂水平[总胆固醇(TC)、甘油三酯(TG)]、临床疗效及不良反应情况。结果与治疗前相比,两组治疗4周后正中神经、腓总神经、胫神经的感觉神经传导速度(SNCV)、运动神经传导速度(MNCV)均发生显著改善(P<0.01),且治疗组以上指标改善效果更为显著(P<0.01)。治疗4周后,两组血浆黏度、全血黏度、全血还原黏度、红细胞压积水平均显著降低(P<0.01),且治疗组下降更为显著(P<0.01)。治疗前后两组TC、TG比较无显著差异(P>0.05),与治疗前相比,两组治疗4周后FBG、PBG均显著改善(P<0.01),且治疗组FBG、PBG改善更为显著(P<0.01)。治疗4周后,治疗组临床疗效总有效率为92.3%,较对照组明显升高(P<0.01)。两组患者在治疗期间均未见明显不良反应。结论应用红花注射液联合小牛血清去蛋白治疗Ⅱ型DPN更能有效缓解或消除患者的症状体征、改善神经传导速度和血液流变学指标,降低血糖,提高治疗效果。

Objective To investigate the clinical effect of type 2 diabetic peripheral neuropathy(DPN)treated with safflower injection combined with deproteinised calf blood serum.Methods 104 patients with typeⅡDPN were enrolled from January 2016 to January 2017,and were randomly divided into two groups.The two groups were given the same basic treatment,the control group patients were given the deproteinised calf blood serum injection treatment,the treatment group patients on the basis of the control group were given safflower injection treatment.The changes of nerve conduction velocity,hemorheology,blood glucose,blood lipid level,clinical efficacy and adverse reactions were compared between the two groups before and after treatment.Results Compared with before treatment,the SNCV and MNCV of the median nerve,peroneal nerve and tibial nerve were significantly improved(P<0.01)in the two groups after 4 weeks of treatment,and the effect of the above indexes was more significant(P<0.01).After 4 weeks of treatment,plasma viscosity,whole blood viscosity,whole blood reduction viscosity and hematocrit were significantly decreased(P<0.01),and the treatment group decreased significantly(P<0.01).There was no significant difference between the two groups(P>0.05).Compared with before treatment,FBG and PBG were significantly improved(P<0.01)in the two groups after 4 weeks of treatment,and the improvement of FBG and PBG in the treatment group was more Significant(P<0.01).After 4 weeks of treatment,the total effective rate was 92.3%in the treatment group,which was significantly higher than that in the control group(P<0.01).There were no significant adverse reactions between the two groups during treatment.Conclusion The treatment of typeⅡDPN with safflower injection combined with deproteinised calf blood serum is effective in relieving or eliminating the symptoms and signs of patients,improving nerve conduction velocity and hemorheology,lowering blood glucose and improving the therapeutic effect.