靶点热凝与臭氧治疗腰椎间盘突出症的效果及对血清炎症因子、NO、SOD水平的影响

Effect of target thermocoagulation and ozone on protrusion of lumbar intervertebral disc and its effect on serum levels of inflammatory factors,NO and SOD

目的探讨靶点热凝与臭氧治疗腰椎间盘突出症的效果及对血清炎症因子、一氧化氮(NO)、超氧化物歧化酶(SOD)水平的影响。方法选取收治的120例腰椎间盘突出症患者进行前瞻性研究,收集时间2016年9月至2017年2月。采用随机数字表法分为研究组和对照组各60例。研究组采用靶点热凝与臭氧治疗,对照组仅采取靶点热凝治疗。对比两组的临床效果、疼痛情况及NO、SOD、IL-1β、IL-6、TNF-α水平。结果术前,两组患者的视觉模拟评分(VAS)差异无统计学意义(P>0.05);术后3 d、术后1周、术后3个月,两组患者的VAS评分较术前均显著降低(P<0.05),且研究组的VAS评分在术后3 d、术后1周、术后3个月均低于对应时间点的对照组患者(P<0.05);术后3个月进行临床疗效评价,研究组优48.33%,良33.33%,可11.67%,差6.67%,对照组优36.67%,良25.00%,可23.33%,差15.00%,研究组疗效优于对照组,两组比较差异具有统计学意义(P<0.05);术后1周,两组患者的血清NO、IL-1β、IL-6、TNF-α水平较本组术前均显著降低(P<0.05),血清SOD较术前显著升高(P<0.05);术后1周,研究组的血清NO、IL-1β、IL-6、TNF-α水平均显著低于对照组(P<0.05),SOD显著高于对照组(P<0.05)。结论靶点热凝与臭氧治疗腰椎间盘突出症效果优于单纯靶点热凝,能有效减轻患者疼痛、降低血清NO、炎症反应程度及升高SOD,从而达到提高治疗效果的目的。

Objective To investigate the effect of target thermocoagulation and ozone therapy on lumbar disc herniation and its effects on serum inflammatory factors,nitric oxide(NO)and superoxide dismutase(SOD)levels.Methods 120 cases of lumbar disc herniation admitted to our hospital for prospective study from September 2016 to February 2017 were divided into study group and control group with 60 cases in each group.The study group were given the target thermal coagulation and ozone treatment,the control group were treated with only target thermal coagulation therapy;the clinical efficacy of the two groups and related laboratory indicators were ovserved.Results There was no significant difference in VAS score between the two groups before surgery(P>0.05).VAS scores of the two groups were significantly decreased 3 days after operation,1 week after operation and 3 months after operation(P<0.05).The VAS score of the study group was lower than that of the control group at 3 days,1 week and 3 months after operation(P<0.05),and 3 months after operation,the efficacy of the study group was 48.33%,good 33.33%,good 11.67%,poor 6.67%,good control 36.67%,good 25.00%,23.33%,poor 15.00%,the difference between the two groups was statistically significant(P<0.05).After 1 week,the levels of NO,IL-1β,IL-6 and TNF-αin the two groups were significantly lower than those before operation(P<0.05).The level of SOD was higher than before operation(P<0.05).The levels of NO,IL-1β,IL-6 and TNF-αin the study group were significantly lower than those in the control group(P<0.05).The level of SOD was higher than the control group(P<0.05).Conclusion Targeted thermal coagulation and ozone treatment of lumbar disc herniation is better than the simple target of thermal coagulation,can effectively reduce the patient's pain,reduce serum NO,inflammatory response and increased SOD.So as to achieve the purpose of improving the therapeutic effect.