华蟾素注射液联合氨酚羟考酮治疗中重度癌性内脏痛的疗效观察

Observation on the efficacy of Hua Chan element injection combined acetaminophen oxycodone in remission of moderately severe pain caused by cancer

目的观察华蟾素注射液联合氨酚羟考酮治疗中重度癌性内脏痛的临床效果。方法采用前瞻性研究方法选取2013年5月至2016年4月收治的82例中重度癌性内脏痛患者,随机分为对照组和观察组各41例,对照组患者应用氨酚羟考酮治疗,观察组应用氨酚羟考酮联合给予华蟾素注射液治疗。对比分析两组患者的疼痛缓解率、疼痛强度和KPS评分,以及不良反应发生情况。结果两组患者用药后疼痛缓解率观察组明显高于对照组(P<0.05)。用药前两组患者疼痛强度及KPS评分比较,差异无统计学意义(P>0.05);用药后两组患者疼痛强度及KPS评分均较治疗前明显改善(P<0.05),观察组改善程度明显优于对照组(P<0.05)。两组患者用药后及用药期间不良反应发生率比较,观察组明显低于对照组(P<0.05)。结论临床应用华蟾素注射液联合氨酚羟考酮治疗中重度癌性内脏痛可有效缓解患者疼痛,提高患者生活质量,安全性高,值得临床推广应用。

Objective To observe the efficacy of clinical application of HuaChan element injection combined acetaminophen oxycodone in remission of moderately severe pain caused by cancer.Methods This is a prospective study carried out in 82 patients with severe pain caused by cancer in this hospital during May 2013 to April 2016,they were divided into control group and observation group by multicenter randomized controlled trial method,with 41 cases in each group.Patients in control group were administrated with acetaminophen oxycodone for treatment,and patients in observation group were applied with acetaminophen oxycodone combined with HuaChan element injection for treatment The pain relief rate,the degree of pain intensity,KPS scores and incidence of adverse reactions were compared between these 2 groups of patients.Results The pain relief rate of patients in observation group was significantly higher than that of patients in control group(P<0.05).The difference in pain intensity and KPS scores compared between these 2 groups had no statistical significance(P>0.05).The pain intensity and KPS scores were obviously improved afer the treatment(P<0.05),they were significantly increased in observation group than those of control group(P<0.05),and the incidence of drug adverse reactions during the therapeutic course in observation group was lower than that of control group(P<0.05).Conclusion The clinical application of HuaChan element injection combined with acetaminophen oxycodone in treatment of moderately severe pain in cancer patients can effectively alleviate pain,improve the quality of living of patients,with high safety,hence it can be popularized for clinical application.