小儿病毒性脑炎运用更昔洛韦与纳洛酮治疗的临床疗效分析

Analysis of Clinical Curative Effect of Ganciclovir and Naloxone in Clinical Treatment of Viral Encephalitis of Infants

目的研究小儿病毒性脑炎运用更昔洛韦与纳洛酮治疗的临床疗效。方法选取2014年8月—2016年8月收治的140例病毒性脑炎患儿为研究对象,按照随机数字表法将其分为两组,每组70例,两组患儿均要采用常规治疗法治疗,在此基础上,给予对照组患儿单独更昔洛韦治疗,给予观察组患儿更昔洛韦与纳洛酮联合治疗,对比两组临床疗效。结果观察组患儿的治疗总有效率为97.14%,显著高于对照组的78.57%,观察组患儿的治疗无效率仅为2.86%,显著低于对照组的21.43%(P<0.05)。结论更昔洛韦联合纳洛酮治疗小儿病毒性脑炎的效果显著,能够有效改善患儿各种临床症状,提高临床治疗总有效率,并且不会增加药物不良反应,是一种安全、有效的治疗方式,在临床上值得广泛推广。

Objective To research the clinical curative effect of ganciclovir and naloxone in clinical treatment of viral encephalitis of infants.Methods 140 cases of infants with viral encephalitis admitted and treated in our hospital from August 2014 to August 2016 were selected as the research objects and randomly divided into two groups with 70 cases in each,both group used the routine treatment method,while the control group used the single ganciclovir treatment,while the observation group were treated with ganciclovir and naloxone,and the clinical curative effect was compared between the two groups.Results The total treatment effective rate in the observation group was obviously higher than that in the control group(97.14%vs 78.57%),and the treatment ineffective rate in the observation group was obviously lower than that in the control group(2.86%vs 21.43)(P<0.05).Conclusion The effect of ganciclovir and naloxone in clinical treatment of viral encephalitis of infants is obvious,which can effectively improve various clinical symptoms,improve the total treatment effective rate,without increasing the adverse reactions,and it is a safe and effective treatment method,which is worth clinical promotion.