抗NMDA受体脑炎患者1例报道及文献学习

Anti-N-methyl-D-aspartate(NMDA)receptor encephalitis:one case report and literature study

目的探讨抗N-甲基-D-天冬氨酸(NMDA)受体脑炎的临床特点、诊断及治疗,提高对该疾病的认识。方法报道1例抗NMDA受体脑炎患者的临床表现及诊治过程,并总结其临床特征。结果患者为青年女性,表现为精神行为异常及抽搐,意识障碍及通气不足。脑脊液中抗NMDA受体抗体阳性。联合静脉用免疫球蛋白、激素冲击及血浆置换等治疗,患者临床痊愈。结论抗NMDA受体脑炎是一种自身免疫性的、能用血清学方法诊断的疾病。早期明确诊断和给予及时治疗,预后良好。

Objective To investigate the clinical presentation,diagnosis,and treatment of Anti-N-methyl-D-aspartate(NMDA)receptor encephalitis and improve its understanding of the disease.Methods One cage of anti NMDA receptor encephalitis in a previously healthy 20 year old female related to the development of NMDA receptor autoantibodies was reported.The related literature was reviewed and the clinical feature was summarized.Results The patient was a young woman,manifested as abnormal mental behavior and convulsions,consciousness disorders and inadequate ventilation.Cerebrospinal fluid anti NMDA receptor antibody were positive.Combined with intravenous immunoglobulin,hormone shock and plasma replacement therapy,patient was clinically cured.Conclusion Anti NMDA receptor encephalitis is autoimmune diseases that can be diagnose with serological methods.Early diagnosis and timely treatment can promote a better prognosis.