稀释丙泊酚与高浓度丙泊酚用于无痛人工流产手术的效果对比

Effect comparison of the diluent Propofol and high concentration Propofol on painless induced abortion

目的观察使用稀释丙泊酚(0.5%)与高浓度丙泊酚(1%),用于无痛人工流产手术的疗效与不良反应以及用药量。探讨两种麻醉用药浓度的优越性。方法选取2016年8月~2017年7月,在我院妇科门诊自愿要求行无痛人工流产手术的100例早孕妇女,采用随机数字表法将其分为稀释丙泊酚组(既0.5%浓度,丙泊酚200 mg/20 ml+生理盐水20 ml,简称观察组)。高浓度丙泊酚组(既1%浓度,丙泊酚200 mg/20 ml,不稀释,简称对照组),每组50例,比较两组的麻醉效果及不良反应。结果观察组术中出现血压明显下降的发生率,术中出现心率明显下降,术中出现血氧饱和度明显下降的发生率均少于对照组,差异有统计学意义(P<0.05),观察组术中丙泊酚的平均用药量少于对照组,差异有统计学意义(P<0.05),观察组术中注射丙泊酚时发生明显注射痛的发生率少于对照组,差异有统计学意义(P<0.05),观察组注射药物完毕至可唤醒时间,注射药物完毕至恢复自由行走时间均短于对照组,差异有统计学意义(P<0.05);两组患者麻醉方法于术中、术后不良反应等发生率及手术时间比较,差异无统计学意义(P>0.05)。结论稀释丙泊酚用于无痛人工流产手术时,血流动力学稳定,注射痛发生率少,呼吸抑制发生率少,丙泊酚用量减少,苏醒时间更短,可以达到比较理想的麻醉效果。

Objective To observe the efficacy,side effects and dosage of diluent Propofol(0.5%)and high concentration Propofol(1%)for painless induced abortion so as to discuss the superiority of the concentration of two narcotic drugs.Methods From August 2016 to July 2017,100 cases of early pregnancy women who voluntarily requested painless artificial abortion were randomly divided into diluted Propofol group(0.5%concentration,Propofol 200 mg/20 ml+normal saline 20 ml,referred to as the observation group).High concentration Propofol group(1%concentration,Propofol 200 mg/20 ml,no dilution,referred to as the control group),50 cases in each group,the anesthetic effect and adverse reactions were compared between the two groups.Results The incidence of blood pressure decreased significantly,the incidence of heart rate decreased significantly in the operation,the incidence of oxygen saturation decreased significantly in the operation in the observation group were less than those in the control group,the difference was statistically significant(p<0.05),the average dosage of Propofol in the observation group surgery was less than the control group,the difference was statistically significant(P<0.05),the incidence of obvious injection pain when Propofol injection in the observation group surgery was less than the control group,the difference was statistically significant(p<0.05),In the observation group,the time from the end of drug injection to the wake-up time and the time from the end of drug injection to the recovery of free walking were shorter than those in the control group(P<0.05).There was no significant difference between the two groups in the incidence of intraoperative and postoperative adverse reactions and operation time(P<0.05).Conclusion Application of Propofol in painless induced abortion operations has the advantages of stable hemodynamics,low incidence of injection pain and respiratory depression,less Propofol dosage,and shorter recovery time,which can achieve an ideal anesthesia effect.