检测子宫上皮细胞游离亚铁原卟啉与人类乳头瘤病毒在宫颈癌筛查中的价值

The clinical values of cells free ferrous protoporphyrin and high-risk HPV examination in the screening of cervical carcinoma

目的探讨宫颈微环境中细胞游离亚铁原卟啉(FH)检测在宫颈癌筛查中的应用价值。方法回顾性分析120例同时行FH、人类乳头瘤病毒(HPV)及病理检查者的病例资料。以病理检查结果作为诊断的金标准,通过计算FH检测与HPV检测技术在宫颈癌筛查中的灵敏度、特异度、准确度、阳性预测值、阴性预测值、阳性似然比、阴性似然比及AUC,比较两种检测方法对宫颈病变的检出率。结果 120例受检者中,FH检测:灵敏度为76.47%、特异度为78.26%、准确率为77.50%、阳性预测值为72.22%、阴性预测值为81.82%、阳性似然比为351.76%、阴性似然比为30.07%、AUC为0.774;HPV检测:灵敏度为70.59%、特异度为73.91%、准确率为72.50%、阳性预测值为66.67%、阴性预测值为77.27%、阳性似然比为270.59%、阴性似然比为39.79%、AUC为0.723。结论 FH检测的灵敏度与HPV检测相当,对宫颈癌的筛查有一定临床应用价值。

Objective To investigate clinical values of cells free ferrous protoporphyrin examination in the screening of cervical carcinoma.Methods A retrospective analysis of data from January 2016 to November 2017 with FH examination of 120 cases were proved by cervical pathological examination in Anhui Provincial Hospital.The pathology results as the gold standard for diagnosis,the sensitivity,specificity,positive predictive value,negative predictive value,accuracy positive and negative likelihood ratio and AUC of FH detection,LCT detection and HPV detection were calculated in the screening of cervical cancer.Results 120 cases underwent FH detection,HPV detection and pathological examination,the sensitivity of FH test was 76.47%,specificity was 78.26%,accuracy was 77.50%,positive predictive value was 72.22%,negative predictive value was 81.82%,positive likelihood ratio was 351.76%,negative likelihood ratio was 30.07%,AUC was 0.774;HPV 70.59%specificity of sensitivity test results was 73.91%and accuracy rate was 72.50%,the positive predictive value was 66.67%and negative predictive value was 77.27%,the positive likelihood ratio was 270.59%,negative likelihood ratio was 39.79%,AUC was 0.723.Conclusions The sensitivity of FH examination is similar to that of LCT and high-risk HPV.It has certain clinical value in the screening of cervical carcinoma.