中性粒细胞/淋巴细胞比值与D-二聚体在深静脉血栓诊断中的价值

The diagnostic value of NLR and D-dimmer in patients with deep venous thrombosis

目的探讨中性粒细胞/淋巴细胞比值(NLR)和D-二聚体在下肢深静脉血栓(DVT)诊断中的价值。方法选取DVT患者180例,其中男88例,女92例;健康对照组为216名健康体检者,其中男124例,女92例。分析两组白细胞计数、中性粒细胞计数、淋巴细胞计数、NLR和D-二聚体水平,并进行比较。结果 DVT组白细胞、中性粒细胞、NLR和D-二聚体水平显著高于健康对照组(P<0.001),而淋巴细胞计数比健康对照组明显降低(P<0.001)。Logistic分析显示:NLR、D-二聚体与深静脉血栓的发生呈正相关(P<0.05)。两者在深静脉血栓中的诊断敏感性分别为65.6%和95.6%,阴性预测价值分别为76.7%和96%,NLR的ROC曲线下面积大小为0.871,D-二聚体的为0.963。结论 NLR和D-二聚体可作为下肢深静脉血栓的辅助诊断指标,NLR的阳性诊断价值较高。

Objective To investigate the diagnostic value of neutrophil to lymphocyte ratio(NLR)and D-dimmer in patients with deep venous thrombosis.Methods 180 patients with deep venous thrombosis(88 males,92 females)and 216 healthy controls(124 males,92 females)were retrospectively enrolled.The leukocytes,neutrophile,lymphocytes and D-dimmer of the two groups were detected and their NLR were calculated and compared.Results The counts of leukocytes and neutrophile and level of D-dimmer were remarkably higer in DVT than those in control group(P<0.05),while the counts of lymphocytes were lower in DVT than that in control group(P<0.05).Logistic analysis showed the level of NLR and D-dimmer was strongly correlated with deep venous thrombosis(P<0.05).Diagnostic sensitivity of NLR and D-dimmer was 65.6%and 95.6%in DVT,while negative predictive value was 76.7%and 96%.ROC curve analysis showed area under curve of NLR(0.871)and D-dimmer(0.963).Conclusion NLR and D-dimmer can be used as complementary diagnostic marker of deep venous thrombosis,and the positive diagnostic value of NLR is higher.