循环肿瘤细胞的检测及其在肺癌诊疗中的应用

The circulating tumor cells and its advance in the of diagnosis and treatment of lung cancer

肺癌的高转移率和高复发率是导致肺癌患者病死率居高不下的主要原因。循环肿瘤细胞(CTCs)是存在于肿瘤患者外周血中的一类特殊细胞,可以作为肿瘤标志物用于监测肿瘤状态。CTCs检测可应用于肿瘤患者早期诊断、疗效评价、预后评估以及个体化治疗等方面。该文阐述CTCs的生物学特性,同时比较不同CTCs检测技术的原理及优缺点,探讨CTCs在肺癌临床诊疗中的应用价值。随着科学研究的不断深入,CTCs将为肺癌的诊断治疗提供新的方向。

The high mortality rate in patients with lung cancer is largely due to the high recurrence and metastasis rate.Circulating tumor cells,a special kind of peripheral blood cells,exist in peripheral blood of patients,and it can be used as a biomarker for monitoring tumor.Recently,we have seen dramatic advancement in exploring the role of CTCs in terms of diagnosis,treatment response,prognosis prediction and,finally,personalized medicine.The aims of this review are to understand the biological feature of CTCs sand to compare methods of detecting CTCs that apply to the various types of solid tumor.Furthermore,we explore the clinical applications of CTCs,including diagnosis and treatment,in the context of lung cancer.With further research,CTCs will provide a new direction for the diagnosis and treatment of lung cancer.