小剂量喹硫平联合艾司西酞普兰对老年期抑郁症治疗的临床分析

Clinical Analysis of Small Dose Quetiapine Combined with Escitalopram in the Treatment of Senile Depression

目的分析观察小剂量喹硫平联合艾司西酞普兰对老年期抑郁症治疗的临床效果。方法随机抽取该院2014年9月—2016年11月70例老年期抑郁症患者,分为对照组(n=35)与观察组(n=35),对照组予以小剂量喹硫平的治疗方法,观察组予以小剂量喹硫平联合艾司西酞普兰的治疗方法。观察两组患者的临床效果,同时观察两组患者治疗后的第3周、第5周、第8周的HAMD评分与不良反应。结果观察患者的总有效率为88.57%,明显高于对照组患者的65.71%(χ2=5.185,P=0.023),同时治疗8 d后的HAMD评分为(7.4±3.2)分,明显低于对照组患者的(13.9±3.8)分(t=7.741,P=0.000),差异有统计学意义(P<0.05),并且观察组与对照组的不良反应发生率分别为11.43%与17.14%(χ2=0.467,P=0.495),差异无统计学意义(P>0.05)。结论小剂量喹硫平联合艾司西酞普兰能够有效的治疗老年期抑郁症,具有较高的临床推广价值。

Objective This paper tries to analyze the efficacy of low-dose quetiapine combined with escitalopram on senile depression.Methods 70 cases of senile depression patients were randomly selected in this hospital from September 2014 to November 2016,were divided into control group(n=35)and observation group(n=35),the control group was treated with low dose of quetiapine the treatment method,the observation group was treated with small dose quetiapine combined with escitalopram.The clinical effect of two groups were observed at the same time,two groups of patients after treatment of third weeks,fifth weeks,HAMD score and adverse reactions in 8 weeks were compared.Results The total effective of observation group was 88.57%,significantly higher than those in control group 65.71%(χ2=5.185,P=0.023),and 8 weeks after treatment HAMD score was(7.4±3.2)points,significantly lower than the control group of(13.9±3.8)points(t=7.741,P=0.000),with the difference was statistical significance(P<0.05),and adverse reactions in the observation group and the control group were 11.43%and 17.14%(χ2=0.467,P=0.495),the difference was not statistically significant(P>0.05).Conclusion Small dose of quetiapine combined with escitalopram can be effective in the treatment of senile depression,which has a high clinical value.