艾司西酞普兰联合认知行为疗法在难治性抑郁症中的临床研究

Clinical Study of Escitalopram in Combination with Cognitive Behavioral Therapy in Refractory Depression

目的探讨难治性抑郁症患者采用艾司西酞普兰联合认知行为疗法进行治疗的临床效果。方法随机选择该院2014年9月—2016年9月收治的难治性抑郁症疾病患者80例,随机分为对照组和治疗组,平均每组40例。对照组采用艾司西酞普兰进行治疗;治疗组采用艾司西酞普兰联合认知行为疗法进行治疗。对比两组心理状态恢复正常时间和用药总时间、抑郁症药物控制总有效率、用药期间不良事件发生例数、用药前后GQOLI和HAMD评分的改善幅度。结果观察组抑郁症药物控制总有效率达到62.5%,高于对照组的45.0%,差异有统计学意义(P<0.05);治疗组患者用药后GQOLI评分为(71.29±4.03)分和HAMD评分为(9.74±1.39)分的改善幅度大于对照组的GQOLI评分(53.86±4.17)分和HAMD评分(17.43±2.95)分,组间差异有统计学意义(P<0.05);用药期间仅有1例不良事件发生,少于对照组的8例,差异有统计学意义(P<0.05)。结论难治性抑郁症患者采用艾司西酞普兰联合认知行为疗法进行治疗,可以在最大程度上控制患者情绪,防止不良事件的发生。

Objective This paper tries to investigate the clinical efficacy of escitalopram combined with cognitive behavior therapy in the treatment of patients with refractory depression.Methods 80 patients with refractory depression from September 2014 to September 2016 in this hospital were randomly divided into control group and treatment group,with 40 cases in each group.The control group was treated with escitalopram,while the treatment group was treated with escitalopram combined with cognitive behavioral therapy.The two groups were compared between the normal state and the total time of medication,the total effective rate of depression medication,the number of adverse events during medication,the GQOLI and HAMD scores before and after treatment.Results The effective rate of study group reached 62.5%,higher than 45.0%in the control group,with the difference was statistically significant(P<0.05).After the administration,the study group GQOLI score was(71.29±4.03)points and HAMD score was(9.74±1.39)points,better than controlled group GQOLI scores was(53.86±4.17)points and HAMD score was(17.43±2.95)points,the difference was statistically significant(P<0.05).There was only one case of adverse events during medication,fewer than 8 cases in the control group,the difference was significant(P<0.05).Conclusion The treatment of patients with refractory depression with citalopram combined with cognitive behavioral therapy can control the mood of patients and prevent the occurrence of adverse events.