两种阿奇霉素序贯疗法治疗儿童肺炎支原体肺炎的疗效分析

Efficacy Analysis of Sequential Treatment of Two Azithromycin in Children with Mycoplasma Pneumoniae Pneumonia

目的探讨不同的阿奇霉素序贯疗法治疗儿童肺炎支原体感染的临床疗效。方法按随机数字法将随机选取2016年1月—2017年1月在该院诊治的100例肺炎支原体感染患儿分为观察组50例和对照组50例,两组患者均接受口服10 mg/kg阿奇霉素治疗,1次/d。其中对照组连续服药3 d后,停4 d,之后再服用3 d;观察组则连续服药5d后,停4 d,再服用3 d。以开始治疗至第14天为观察结点。结果观察组总有效率为94.0%,明显高于对照组的80.0%(P<0.05);观察组MP-Ig M转阴率为96.0%,对照组为82.0%,两组MP-Ig M转阴率比较差异有统计学意义(P<0.05)。与治疗前比较,治疗后两组患者的EOS、IgE、IL-3均显著下降(P<0.05),且治疗后观察组的EOS(215.47±24.58)×104/L、IgE(92.52±10.46)IU/m L、IL-3(167.35±23.96)ng/L均明显低于对照组EOS(289.83±56.09)×104/L、Ig E(125.82±14.17)IU/m L、IL-3(301.89±23.99)ng/L(P<0.05)。结论应用阿奇霉素治疗儿童肺炎支原体感染时,首次口服5 d阿奇霉素序贯疗法疗效优于首次口服3 d,不良反应无变化,可在临床上广泛使用。

Objective This paper tries to investigate the clinical curative effect of different azithromycin sequential therapy in the treatment of mycoplasma pneumoniae pneumonia in children.Methods According to the random number method,100 children with Mycoplasma pneumoniae infection treated in this hospital from January 2016 to January 2017 were random divided into observation group(50 cases)and control group(50 cases).Both groups received oral administration of 10 mg/kg azithromycin treatment,1 time/d.The patients in the control group continued to take medication for 3 d and stopped for 4 days,and then continuing again for 3 d.The patients in the observation group continued to take medication for 5 d and stopped for 4 d before taking 3 d.To start treatment until the 14th day and which was regarded as the observation node.Results The total effective rate in the observation group was 94.0%,which was significantly higher than that in the control group 80.0%(P<0.05).The negative rate of MP-IgM in the observation group was 96.0%and that in the control group was 82.0%.The difference was statistically significant(P<0.05).Compared with before treatment,the EOS,IgE and IL-3 of the two groups were significantly decreased(P<0.05),and the levels of EOS(215.47±24.58)×104/L IgE(92.52±10.46)(IU/ml),IL-3(167.35±23.96)(ng/L)were significantly lower than those of the control group(289.83±56.09)×104/L and IgE(125.82±14.17)IU/mL,IL-3(301.89±23.99)ng/L(P<0.05).Conclusion Azithromycin treatment of children with Mycoplasma pneumoniae infection,the first 5 days of oral azithromycin sequential therapy is better than the first oral administration of 3 days,no adverse reactions,which can be widely used in clinical practice.