两种方案治疗幽门螺杆菌阳性活动性胃溃疡的临床疗效对比分析

Comparison of Clinical Efficacy on Two Kinds of Regimens in Treatment of Helicobacter Pylori Positive Active Gastric Ulcer

目的对奥美拉唑及雷贝拉唑治疗幽门螺杆菌阳性活动性胃溃疡的临床效果进行比较分析。方法该次研究对象为方便选取2016年6月—2017年6月期间该院收治的110例幽门螺杆菌阳性活动性胃溃疡患者,根据硬币法分为奥美拉唑组及雷贝拉唑组,所有患者均实施阿莫西林、克拉霉素及胶体果胶铋进行治疗,在此基础上奥美拉唑组患者加服奥美拉唑进行治疗,雷贝拉唑组患者加服雷贝拉唑进行治疗,对其治疗效果及并发症发生率进行比较分析。结果(1)雷贝拉唑组患者治疗总有效率100.0%比奥美拉唑组患者治疗总有效率85.5%高,差异有统计学意义(χ2=8.627,P<0.05)。(2)雷贝拉唑组患者并发症发生率3.6%比奥美拉唑组患者并发症发生率16.4%低,差异有统计学意义(χ2=4.949,P<0.05)。(3)治疗一星期时雷贝拉唑组患者反酸、腹痛及胃部灼烧感缓解度明显优于奥美拉唑组患者(χ2=6.263、5.681、6.651,P<0.05);治疗两星期时雷贝拉唑组患者反酸、腹痛及胃部灼烧感缓解度明显优于奥美拉唑组患者(χ2=8.461、9.386、10.523,P<0.05);治疗1个月时雷贝拉唑组患者反酸、腹痛及胃部灼烧感缓解度明显优于奥美拉唑组患者(χ2=7.475、9.802、8.627,P<0.05)。结论雷贝拉唑治疗幽门螺杆菌阳性活动性胃溃疡具有效果好,安全性高的优势。

Objective This paper tries to compare the clinical effects of omeprazole and rabeprazole in the treatment of helicobacter pylori-positive active gastric ulcer.Methods 110 patients with helicobacter pylori-positive gastric ulcer in this hospital from June 2016 to June 2017 were conveniently selected,according to the coin method,they were divided into the omeprazole group and rabeprazole group,all patients were treated with amoxicillin,clarithromycin and colloidal bismuth pectin,on this basis,patients in omeprazole group were treated with omeprazole and rabeprazole group was treated with rabeprazole.The therapeutic effect and complication rate were compared.Results①The total effective rate was 100.0%in the rabeprazole group and 85.5%in the omeprazole group,which was statistically significant after statistical analysis(χ2=8.627,P<0.05).②The incidence of complication in rabeprazole group was lower than that in the omeprazole group(3.6%vs 16.4%),which was statistically significant after statistical analysis(χ2=4.949,P<0.05).③The patients in rabeprazole group had significantly better anti-acid,abdominal pain and stomach burning sensation than those in omeprazole group after one week treatment(χ2=6.263,5.681,6.651,P<0.05).The patients in the rabeprazole group had significantly better anti-acid,abdominal pain and stomach burning sensation than those in the omeprazole group in two weeks treatment(χ2=8.461,9.386,10.523,P<0.05);Acidity,abdominal pain and stomach burning sensation were significantly better than omeprazole group for a month treatment(χ2=7.475,9.802,8.627,P<0.05).Conclusion Rabeprazole treatment of Helicobacter pylori positive active gastric ulcer has the advantages of good effect,high safety.