替普瑞酮治疗慢性萎缩性胃炎的临床体会

Clinical Experience of Teprenone in the Treatment of Chronic Atrophic Gastritis

目的总结替普瑞酮治疗慢性萎缩性胃炎的效果,为胃炎用药治疗提供参考。方法实验方便选择确诊并收治药物治疗的92例(2014年1月—2016年12月)慢性萎缩性胃炎患者,分为人数均等的两组进行治疗方案对比,即采取常规治疗的对照组以及常规治疗基础上加用替普瑞酮治疗的观察组,每组患者46例。对比两组慢性萎缩性胃炎患者的胃镜复查结果、治疗前后症状积分变化、药物不良反应情况。结果治疗前患者症状积分结果对比,差异无统计学意义(P>0.05)。治疗后对比治疗前两组慢性萎缩性胃炎患者症状均有改善且观察组改善幅度大于对照组。另外,观察组患者总有效率为91.30%,对照组者总有效率为71.73%,组间胃镜复查结果对比观察组优于对照组。经统计学软件计算差异有统计学意义(P<0.05)。另外,患者治疗期间无严重不良反应问题。结论用替普瑞酮治疗慢性萎缩性胃炎在症状改善方面、治疗方面效果均优于常规治疗,且无显著不良反应表现,具有临床实施价值。

Objective This paper tries to summarize the effect of teprenone in the treatment of chronic atrophic gastritis and to provide a reference for the treatment of gastritis.Methods A total of 92 patients from January 2014 to December 2016 who had been diagnosed and treated with chemotherapy were conveniently selected in this study.The patients were divided into equal numbers of two groups to compare treatment options,that is,to take the conventional treatment of the control group and conventional treatment plus teprenone treatment in the observation group,with 46 patients in each group.Comparing the two groups of patients with chronic atrophic gastroscopy review results,symptom scores before and after treatment,adverse drug reactions.Results The symptom score of the patients before treatment was not significantly different(P>0.05).After treatment,the symptoms of both groups of patients with chronic atrophic gastritis were improved and the improvement rate of the observation group was higher than that of the control group.In addition,the total effective rate was 91.30%in the observation group and 71.73%in the control group.The results of the endoscopic examination were better than the control group.According to the statistical software(P<0.05).In addition,there was no serious adverse reactions during the treatment of the patient.Conclusion Treatment of chronic atrophic gastritis with teprenone in the improvement of symptoms,the treatment effect is superior to conventional treatment,with no significant adverse reactions,which has clinical value.