二甲双胍对认知功能的改善研究

Study on Improvement Effect of Metformin on Cognitive Function

目的该次实验将针对二甲双胍对阿尔茨海默病患者认知功能的改善情况进行着重分析。方法该次实验便利选取了2016年3月—2017年5月在该院就诊的60例阿尔茨海默病患者为研究对象,随机分为对照组和观察组,对照组采用单纯改善脑功能治疗,观察组则在此基础上加用二甲双胍治疗,并对比有效性。结果两组患者治疗后在空腹血糖含量(FPG)、血脂水平均有所好转,特别是认知功能上均有明显的改善,且观察组患者表现更佳,具体而言,观察组治疗后FPG为(4.21±0.63)mmol/L,对照组则为(4.55±0.41)pmol/L;Fins为(18.96±0.54)mmol/L,对照组则为(19.98±0.39)pmol/L;两组差异有统计学意义(P<0.05)。此外,对比了两组患者治疗前后胰岛素抵抗指数情况,治疗前后两组比较均差异有统计学意义。结论采用二甲双胍治疗对阿尔茨海默病患者的认知功能具有显著的改善效果,且配合康复训练,患者恢复程度更好,值得在临床过程中推广应用。

Objective To especially analyze the improvement effect of metformin on cognitive function.Methods 60 cases of patients with alzheimer's disease diagnosed in our hospital from March 2016 to May 2017 were convenient selected and randomly divided into two groups,the control group only improved the cardiac function,while the observation group were treated with metformin on the basis of the control group,and the effectiveness was compared.Results After treatment,the FPG and blood liquid levels of the two groups were improved,especially the cognitive function was obviously improved,and the improvement effect in the observation group was better,and the FPG and Fins in the observation group and in the control group after treatment were respectively(4.21±0.63)mmol/L,(18.96±0.54)pmol/L and(4.55±0.41)mmol/L,(19.98±0.39)pmol/L,and the differences were obvious with statistical significance(P<0.05),besides,the insulin resistance index of the two groups before and after treatment was compared,There were statistically significant differences between the two groups before and after treatment.Conclusion The improvement effect of metformin on cognitive function of alzheimer's disease patients is obvious,and the metformin,combined with the rehabilitation training can have a better recovery degree,and it is worth promotion and application in clinic.