美托洛尔对心力衰竭患者APN和TNF-α水平的影响

Effect of Metoprolol on the APN and TNF-α Levels of Patients with Heart Failure

目的探讨酒石酸美托洛尔对慢性充血性心力衰竭(CHF)的血浆脂联素(adiponectin,APN)和肿瘤坏死因子(TNF-α)水平的影响。方法方便收集2015年1月—2016年1月的福建中医药大学附属人民医院充血性心力衰竭患者80例,随机分为美托洛尔组和常规治疗组,每组40例。治疗12周,测定两组患者治疗前后血浆脂联素和TNF-α浓度。结果治疗后,美托洛尔治疗组治疗后血浆脂联素水平为(6.1±1.8)ng/L,TNF-α水平为(26.4±6.7)ng/L,显著低于常规治疗组(8.2±2.2)、(30.1±4.5)ng/L,差异有统计学意义(P<0.05)。结论美托洛尔能减少充血性心力衰竭患者的血浆脂联素和TNF-α水平,减少二者对心肌的毒性作用,有益于心力衰竭的治疗。

Objective To study the effect of metoprolol on the APN and TNF-αlevels of patients with heart failure.Methods 80 cases of patients with congestive heart-failure in our hospital from January 2015 to January 2016 were conveniently selected and randomly divided into two groups with 40 cases in each for 12 weeks,including the metoprolol group and routine treatment group,and the plasma adiponectin and TNF-αconcentration of the two groups before and after treatment were measured.Results After treatment,the plasma adiponectin and TNF-αlevels in the metoprolol treatment group were obviously lower than those in the routine treatment group[(6.1±1.8),(26.4±6.7)ng/L vs(8.2±2.2),(30.1±4.5)ng/L],the difference was statistically significant(P<0.05).Conclusion The metoprolol can reduce the APN and TNF-αlevels of patients with heart failure,reduce the effect on the myocardial toxicity,and it is beneficial to treatment of heart failure.