抑郁症患者血清维生素B_(12)和叶酸水平研究

Serum Folic Acid and Vitamin B_(12) Levels in Patients with Depression

目的检测抑郁症患者血清维生素B_(12)、叶酸的水平并探讨其与健康人群的差异。方法采用电化学发光免疫分析方法对148例抑郁症患者(抑郁症组)和160例健康人群(健康对照组)进行血清维生素B_(12)和叶酸的测定,比较抑郁症组与健康对照组血清维生素B_(12)和叶酸水平。结果抑郁症组血清维生素B_(12)和叶酸的质量浓度分别为(527.28±173.74)pg·mL^(-1)和(7.03±3.52)ng·mL^(-1),健康对照组血清维生素B_(12)和叶酸的质量浓度分别为(669.67±336.89)pg·mL^(-1)和(7.93±4.00)ng·mL^(-1),抑郁症组血清维生素B_(12)和叶酸水平均低于健康对照组(P=0.000,P=0.038)。结论抑郁症患者的血清维生素B_(12)和叶酸水平低于健康人群。

Objective To detect serum levels of folic acid and vitamin B 12 in patients with depression,and to investigate their differences between depression patients and healthy persons.Methods Serum folic acid and vitamin B 12 levels were detected by electrochemiluminescence immunoassay in 148 depression patients(depression group)and 160 healthy subjects(control group).Results The concentrations of vitamin B 12 and folic acid in depression group((527.28±173.74)pg·mL-1 and(7.03±3.52)pg·mL-1,respectively)were lower than those in control group((669.67±336.89)pg·mL-1 and(7.93±4.00)ng·mL-1,respectively)(P=0.000 and P=0.038,respectively).Conclusion Serum folic acid and vitamin B 12 levels in depression patients are lower than those in healthy persons.