他克莫司治疗老年激素抵抗型肾病综合征的临床有效率分析

Clinical Efficacy of Tacrolimus in the Treatment of Senile Steroid Resistant Nephrotic Syndrome

目的探讨对老年激素抵抗型肾病综合征患者选择他克莫司治疗后获得的临床效果。方法选择我院2015年7月—2017年9月收治的82例老年激素抵抗型肾病综合征患者作为实验对象;采用数字奇偶法分组;临床确定药物治疗方案期间,对照组(41例):选择泼尼松+环磷酰胺药物施治;观察组(41例):选择泼尼松+环磷酰胺+他克莫司药物施治;对两组老年激素抵抗型肾病综合征患者治疗总有效率、血浆白蛋白水平、总胆固醇水平以及24 h尿蛋白水平展开对比。结果同对照组老年激素抵抗型肾病综合征患者治疗总有效率(70.73%)比较,观察组(97.56%)较高(P<0.05);同对照组老年激素抵抗型肾病综合征患者血浆白蛋白水平、总胆固醇水平以及24 h尿蛋白水平比较,观察组获得明显改善(P<0.05)。结论临床对老年激素抵抗型肾病综合征患者选择他克莫司药物加以治疗,临床治疗总有效率提高、蛋白尿症状改善以及肾病综合征表现得到缓解,促进老年激素抵抗型肾病综合征患者的病情好转。

Objective To investigate the clinical effects of tacrolimus in the treatment of senile steroid resistant nephrotic syndrome.Methods 82 cases of senile steroid resistant nephrotic syndrome treated in our hospital from July 2015 to September 2017 were selected as experimental subjects.The digital parity method was used for grouping.The control group(41 cases)was treated with prednisone+cyclophosphamide.The observation group(41 cases)was treated with prednisone+cyclophosphamide plus tacrolimus.The total effective rate,plasma albumin level,total cholesterol level and 24 h urine protein level of two groups of elderly patients with steroid resistant nephrotic syndrome were compared.Results Compared with the control group,the total effective rate of the elderly with steroid resistant nephrotic syndrome(70.73%)was compared.The observation group(97.56%)was higher(P<0.05).Compared with the control group,the plasma albumin level,total cholesterol level and 24 h urine protein level were compared in the elderly with steroid resistant nephrotic syndrome.The observation group was significantly improved(P<0.05).Conclusion Elderly patients with steroid resistant nephrotic syndrome patients for tacrolimus treatment,the overall efficiency of the clinical treatment,the improvement of proteinuria and the symptoms of nephrotic syndrome were relieved,to promote the improvement of the condition of the elderly with steroid resistant nephrotic syndrome.