阿司匹林联合氯吡格雷对急性缺血性脑卒中患者NIHSS评分及日常生活能力的影响

Effect of Aspirin Combined with Clopidogrel on NIHSS Score and Daily Living Ability in Patients with Acute Ischemic Stroke

目的:研究阿司匹林联合氯吡格雷对急性缺血性脑卒中患者神经功能缺损量表(NIHSS)评分及日常生活能力的影响。方法:选取孟津县人民医院2015年3月~2017年3月治疗急性缺血性脑卒中患者78例,随机数表法分为两组,各39例。观察组用氯吡格雷+阿司匹林治疗,对照组用阿司匹林治疗。统计对比两组临床治疗效果及治疗前后NIHSS量表及日常生活评分量表(ADL)评分变化。结果:观察组临床治疗有效率92.31%(36/39)高于对照组71.79%(28/39),差异有统计学意义(P<0.05);治疗后15d、30d与对照组比较,观察组NIHSS评分均较低,差异均有统计学意义(P<0.05);治疗后15d、30d与对照组相比,观察组ADL评分均较高,差异有统计学意义(P<0.05)。结论:阿司匹林及氯吡格雷治疗急性缺血性脑卒中患者,可明显降低患者NIHSS评分,并提高患者日常生活能力,临床疗效显著。

Objective:To investigate the effect of aspirin combined with clopidogrel on neurological deficit scale(NIHSS)score and daily living ability in patients with acute ischemic stroke.Methods:A total of 78 cases of acute ischemic stroke patients treated in our hospital from March 2015 to March 2017 were randomly divided into two groups,39 cases in each.The observation group was treated with clopidogrel+aspirin,and the control group was treated with aspirin.The clinical therapeutic effect and the changes of NIHSS scale and daily life scale(ADL)before and after treatment were compared between the two groups.Results:The effective rate of clinical treatment in the observation group was 92.31%(36/39),which was significantly higher than that of the control group 71.79%(28/39)(P<0.05).Compared with the control group after 15 d and 30 d of treatment,the NIHSS scores of the observation group were significantly lower(P<0.05).Compared with the control group after 15 d and 30 d of treatment,the ADL scores of the observation group were significantly higher(P<0.05).Conclusion:Aspirin combined with clopidogrel in the treatment of acute ischemic stroke patients can significantly reduce the NIHSS score and improve the daily living ability of patients.Besides,the clinical curative effect is remarkable.