DNA甲基化与肺动脉高压患病风险相关性的研究进展

Research progress on the correlation between DNA methylation and the risk of pulmonary arterial hypertension

肺动脉高压是一种严重而无法治愈的肺血管疾病,其发病机制复杂。DNA甲基化是在甲基化转移酶的作用下调控基因选择性转录表达的表观遗传学修饰。近期研究发现,DNA甲基化在肺动脉高压的发生、发展过程中起着重要作用。该文就近年来对DNA甲基化影响肺动脉高压形成的研究作一综述。

Pulmonary arterial hypertension is a serious and incurable pulmonary vascular disease with complex pathogenesis.DNA methylation is an epigenetic modification that electively regulates the transcriptional expression of genes under the action of methyltransferase.Recent studies have demonstrated that DNA methylation plays a crucial role in the incidence and progression of pulmonary arterial hypertension.This review summarizes recent studies focusing upon the effect of DNA methylation on the incidence of pulmonary arterial hypertension.